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A Systems Biology Approach to BloodSystems Approach to Phagocyte Production and Activation: Neutrophils and Monocytes

A Systems Biology Approach to Blood: Systems Approach to Phagocyte Production and Activation:... [Granulocyte differentiation and immune response function is a dynamic process governed by a highly coordinated transcriptional program that regulates cellular fate and function, often in a context-dependent manner. Advances in high-throughput technologies and bioinformatics have allowed us to better understand complex biological processes at the genomic and proteomic levels. Components of the environmental milieu, along with the molecular mechanisms that drive the development, activation, and regulation of granulocytes, have since been elucidated. In this chapter, we present the intricate network in which these elements come together and influence one another. In particular, we describe the critical roles of transcription factors like PU.1, CCAAT/enhancer-binding protein (C/EBPα; alpha), C/EBPε (epsilon), and growth factor independent-1 (Gfi-1). We also review granulocyte colony-stimulating factor (G-CSF) receptor-induced signal transduction pathways, their influence on proliferation and differentiation, and the cooperativity of cytokines and chemokines in this process.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Systems Biology Approach to BloodSystems Approach to Phagocyte Production and Activation: Neutrophils and Monocytes

Part of the Advances in Experimental Medicine and Biology Book Series (volume 844)
Editors: Corey, Seth Joel; Kimmel, Marek; Leonard, Joshua N.
Mehta, Hrishikesh M.; Glaubach, Taly; Corey, Seth Joel
Springer Journals — Dec 6, 2014
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15 pages

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Publisher
Springer New York
Copyright
© Springer Science+Business Media New York 2014
ISBN
978-1-4939-2094-5
Pages
99 –113
DOI
10.1007/978-1-4939-2095-2_6
Publisher site
See Chapter on Publisher Site

Abstract

[Granulocyte differentiation and immune response function is a dynamic process governed by a highly coordinated transcriptional program that regulates cellular fate and function, often in a context-dependent manner. Advances in high-throughput technologies and bioinformatics have allowed us to better understand complex biological processes at the genomic and proteomic levels. Components of the environmental milieu, along with the molecular mechanisms that drive the development, activation, and regulation of granulocytes, have since been elucidated. In this chapter, we present the intricate network in which these elements come together and influence one another. In particular, we describe the critical roles of transcription factors like PU.1, CCAAT/enhancer-binding protein (C/EBPα; alpha), C/EBPε (epsilon), and growth factor independent-1 (Gfi-1). We also review granulocyte colony-stimulating factor (G-CSF) receptor-induced signal transduction pathways, their influence on proliferation and differentiation, and the cooperativity of cytokines and chemokines in this process.]

Published: Dec 6, 2014

Keywords: Systems biology; Phagocyte; Granulocyte; Neutrophil; Macrophage; Transcription factor; Granulopoiesis; Chemotaxis; Phagocytosis; Apoptosis

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