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Absorption, distribution, metabolism, and excretion (ADME) of 14 C-sonidegib (LDE225) in healthy volunteers

Absorption, distribution, metabolism, and excretion (ADME) of 14 C-sonidegib (LDE225) in healthy... Sonidegib exhibited low absorption, was extensively distributed, and was slowly metabolized. Elimination of absorbed sonidegib occurred largely by oxidative and hydrolytic metabolism. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Chemotherapy and Pharmacology Springer Journals

Absorption, distribution, metabolism, and excretion (ADME) of 14 C-sonidegib (LDE225) in healthy volunteers

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References (19)

Publisher
Springer Journals
Copyright
Copyright © 2014 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Oncology; Pharmacology/Toxicology; Cancer Research
ISSN
0344-5704
eISSN
1432-0843
DOI
10.1007/s00280-014-2468-y
pmid
24817600
Publisher site
See Article on Publisher Site

Abstract

Sonidegib exhibited low absorption, was extensively distributed, and was slowly metabolized. Elimination of absorbed sonidegib occurred largely by oxidative and hydrolytic metabolism.

Journal

Cancer Chemotherapy and PharmacologySpringer Journals

Published: Jul 1, 2014

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