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Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture Acupuncture can locally reduce pain, but it has remained unclear how it might work. Goldman et al. find that acupuncture elevates local tissue adenosine levels in a mouse model. The anti-nociceptive effect of acupuncture was absent in mice lacking the adenosine receptor A1. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Neuroscience Springer Journals

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References (49)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Nature Publishing Group
Subject
Biomedicine; Biomedicine, general; Neurosciences; Behavioral Sciences; Biological Techniques; Neurobiology; Animal Genetics and Genomics
ISSN
1097-6256
eISSN
1546-1726
DOI
10.1038/nn.2562
Publisher site
See Article on Publisher Site

Abstract

Acupuncture can locally reduce pain, but it has remained unclear how it might work. Goldman et al. find that acupuncture elevates local tissue adenosine levels in a mouse model. The anti-nociceptive effect of acupuncture was absent in mice lacking the adenosine receptor A1.

Journal

Nature NeuroscienceSpringer Journals

Published: May 30, 2010

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