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Ameliorative Effect of Quercetin on Neurotoxicogical Alterations Induced by Carbendazim: Oxidative Stress, Biochemicals, and Histopathology

Ameliorative Effect of Quercetin on Neurotoxicogical Alterations Induced by Carbendazim:... In the present study, an attempt was made to evaluate the effect of sub-acute exposure of carbendazim (CBZ) on male rats for the neurotoxicity, oxidative stress, histopathological alterations, and ameliorative potential of quercetin (QRT) against CBZ toxicity. Adult male Sprague Dawley rats were exposed to CBZ (100, 200, and 400 mg/kg body weight) and QRT (25 mg/kg body weight) alone and in combinations by oral gavage. At the end of the experiment, the levels of lipid peroxidation, protein carbonyl, nitric oxide, and GST were increased significantly (p < 0.05), while SOD, GPx, GSH, and CAT activities were decreased in CBZ treatments. CBZ exposure was responsible for the decrease in AChE and BuChE activity in a dose-dependent manner. CBZ administration caused a decrease (p < 0.05) in locomotor activity and grip strength. CBZ-exposed rats showed cell shrinkage, peri-neuronophagic attempts by microglial cells, vacuolization in white matter, neuronal fragmentation, degeneration, neuronal chromatolysis, and vacuolar change in the white matter of the brain. However, QRT administration in CBZ-treated animals effectively protected cellular and biochemical alterations in the brain. The results of the present study suggest that QRT has the potential to mitigate the CBZ-mediated neurotoxicosis in rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Proceedings of the National Academy of Sciences India Section B Biological Sciences Springer Journals

Ameliorative Effect of Quercetin on Neurotoxicogical Alterations Induced by Carbendazim: Oxidative Stress, Biochemicals, and Histopathology

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References (63)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to The National Academy of Sciences, India 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
0369-8211
eISSN
2250-1746
DOI
10.1007/s40011-022-01420-9
Publisher site
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Abstract

In the present study, an attempt was made to evaluate the effect of sub-acute exposure of carbendazim (CBZ) on male rats for the neurotoxicity, oxidative stress, histopathological alterations, and ameliorative potential of quercetin (QRT) against CBZ toxicity. Adult male Sprague Dawley rats were exposed to CBZ (100, 200, and 400 mg/kg body weight) and QRT (25 mg/kg body weight) alone and in combinations by oral gavage. At the end of the experiment, the levels of lipid peroxidation, protein carbonyl, nitric oxide, and GST were increased significantly (p < 0.05), while SOD, GPx, GSH, and CAT activities were decreased in CBZ treatments. CBZ exposure was responsible for the decrease in AChE and BuChE activity in a dose-dependent manner. CBZ administration caused a decrease (p < 0.05) in locomotor activity and grip strength. CBZ-exposed rats showed cell shrinkage, peri-neuronophagic attempts by microglial cells, vacuolization in white matter, neuronal fragmentation, degeneration, neuronal chromatolysis, and vacuolar change in the white matter of the brain. However, QRT administration in CBZ-treated animals effectively protected cellular and biochemical alterations in the brain. The results of the present study suggest that QRT has the potential to mitigate the CBZ-mediated neurotoxicosis in rats.

Journal

Proceedings of the National Academy of Sciences India Section B Biological Sciences – Springer Journals

Published: Jun 1, 2023

Keywords: Carbendazim; Quercetin; Brain damage; Locomotor activity; Antioxidants; Acetylcholinesterase

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