Get 20M+ Full-Text Papers For Less Than $1.50/day. Subscribe now for You or Your Team.

Learn More →

An evolutionary perspective on field cancerization

An evolutionary perspective on field cancerization Mutations naturally accrue and clonally expand in ageing tissues, but only a subset of these mutations increases the risk of cancer development. A cancerized lineage is one that has acquired some but not all the phenotypic traits required for malignancy. Typically, this means that a cancerized lineage has a survival or growth advantage over normal cells but is incapable of growing into a tumour. Field cancerization is both enabled by and causes changes to the tissue microenvironment. Mutagen exposure and naturally occurring age-related mutations initiate cancerized fields. Field cancerization can occur without morphological change, meaning that histopathology of a tissue alone is an inadequate biomarker of cancer risk. Measurements of the evolution of the cancerized field offer promise as a new class of biomarker of cancer risk and provide a means to mechanistically assess the impact of chemoprevention strategies. Longitudinally collected tissue samples from patients undergoing surveillance in tissues frequently affected by field cancerization provide an underexploited resource for the study of clonal evolution over space and time in humans. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Reviews Cancer Springer Journals

An evolutionary perspective on field cancerization

Loading next page...
 
/lp/springer-journals/an-evolutionary-perspective-on-field-cancerization-U5hhMfLW1Y

References (225)

Publisher
Springer Journals
Copyright
Copyright © 2017 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Biomedicine; Biomedicine, general; Cancer Research
ISSN
1474-175X
eISSN
1474-1768
DOI
10.1038/nrc.2017.102
Publisher site
See Article on Publisher Site

Abstract

Mutations naturally accrue and clonally expand in ageing tissues, but only a subset of these mutations increases the risk of cancer development. A cancerized lineage is one that has acquired some but not all the phenotypic traits required for malignancy. Typically, this means that a cancerized lineage has a survival or growth advantage over normal cells but is incapable of growing into a tumour. Field cancerization is both enabled by and causes changes to the tissue microenvironment. Mutagen exposure and naturally occurring age-related mutations initiate cancerized fields. Field cancerization can occur without morphological change, meaning that histopathology of a tissue alone is an inadequate biomarker of cancer risk. Measurements of the evolution of the cancerized field offer promise as a new class of biomarker of cancer risk and provide a means to mechanistically assess the impact of chemoprevention strategies. Longitudinally collected tissue samples from patients undergoing surveillance in tissues frequently affected by field cancerization provide an underexploited resource for the study of clonal evolution over space and time in humans.

Journal

Nature Reviews CancerSpringer Journals

Published: Dec 8, 2017

There are no references for this article.