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Anti-Venom Potential of Canthium parviflorum Against Naja naja Venom by In Vitro and In Vivo Studies

Anti-Venom Potential of Canthium parviflorum Against Naja naja Venom by In Vitro and In Vivo Studies Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. https://doi.org/10.1007/s40011-017-0959-4 RESEARCH ARTICLE Anti-Venom Potential of Canthium parviflorum Against Naja naja Venom by In Vitro and In Vivo Studies 1 1 2 • • Vineetha M. Shrikanth Bhavya Janardhan Sunil S. More Received: 19 January 2017 / Revised: 21 December 2017 / Accepted: 27 December 2017 The National Academy of Sciences, India 2018 Abstract Plant extracts are extensively used in folk med- survival time was prolonged due to plant extract. At 1:10 icine to treat the snake bites. In the present study, anti- and 1:20 of venom: plant extract concentration (w/w) sig- venom potential of Canthium parviflorum root extracts nificantly neutralized edema and myotoxic effects respec- against Naja naja venom was studied by in vitro and tively in mice model. The present study revealed the in vivo methods. Ethyl acetate and methanolic root extracts potential of C. parviflorum root extract for its anti-venom were analysed for in vitro neutralization of 5 -nucleotidase, properties and the plants could be considered as a potential phospholipase A , acetylcholinesterase, phosphodiesterase, source of anti-venom phytoconstituents. hyaluronidase, phosphomonoesterase and protease enzyme activities. Neutralization of pharmacological activities like Keywords Naja naja  Canthium parviflorum fibrinogenolytic, and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Proceedings of the National Academy of Sciences, India Section B: Biological Sciences Springer Journals

Anti-Venom Potential of Canthium parviflorum Against Naja naja Venom by In Vitro and In Vivo Studies

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References (38)

Publisher
Springer Journals
Copyright
Copyright © 2018 by The National Academy of Sciences, India
Subject
Life Sciences; Life Sciences, general; Behavioral Sciences; Plant Biochemistry; Nucleic Acid Chemistry
ISSN
0369-8211
eISSN
2250-1746
DOI
10.1007/s40011-017-0959-4
Publisher site
See Article on Publisher Site

Abstract

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. https://doi.org/10.1007/s40011-017-0959-4 RESEARCH ARTICLE Anti-Venom Potential of Canthium parviflorum Against Naja naja Venom by In Vitro and In Vivo Studies 1 1 2 • • Vineetha M. Shrikanth Bhavya Janardhan Sunil S. More Received: 19 January 2017 / Revised: 21 December 2017 / Accepted: 27 December 2017 The National Academy of Sciences, India 2018 Abstract Plant extracts are extensively used in folk med- survival time was prolonged due to plant extract. At 1:10 icine to treat the snake bites. In the present study, anti- and 1:20 of venom: plant extract concentration (w/w) sig- venom potential of Canthium parviflorum root extracts nificantly neutralized edema and myotoxic effects respec- against Naja naja venom was studied by in vitro and tively in mice model. The present study revealed the in vivo methods. Ethyl acetate and methanolic root extracts potential of C. parviflorum root extract for its anti-venom were analysed for in vitro neutralization of 5 -nucleotidase, properties and the plants could be considered as a potential phospholipase A , acetylcholinesterase, phosphodiesterase, source of anti-venom phytoconstituents. hyaluronidase, phosphomonoesterase and protease enzyme activities. Neutralization of pharmacological activities like Keywords Naja naja  Canthium parviflorum fibrinogenolytic, and

Journal

Proceedings of the National Academy of Sciences, India Section B: Biological SciencesSpringer Journals

Published: Jan 8, 2018

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