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Antibacterial and Antioxidant Activities and Anticancer Effects of Fennel Seeds (Foeniculum vulgare) Against Lung Cancer Cells

Antibacterial and Antioxidant Activities and Anticancer Effects of Fennel Seeds (Foeniculum... Natural anti-bacterial materials have received particular attention due to their higher food protection. The recent research was performed to evaluate the antioxidant, antimicrobial, and anticancer impacts of methanolic extract of Fennel (Foeniculum vulgare) seeds. To this aim, the methanolic extract was made following preparation of the Fennel seeds. The chemical compounds of the extract was determined using Gas–Liquid Chromatography-Mass Spectrometry. To evaluate the antioxidant impact of the methanolic extract of fennel, 2,2-diphenyl-1-picrylhydrazyl technique was applied for 7 concentrations of 200, 100, 50, 25, 22.5, 6.25 and 3 ppm. The antimicrobial impacts of the extract were evaluated using the inhibition zones process on isolates, including Streptococcus pyogenes, Streptococcus pneumonia, Klebsiella, pneumonia, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. In order to assess the anticancer activity of the extract in A549 cell line (Human lung cancer cell line), MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide-2-yl)-2,5-diphenyltetrazolium bromide assay) was done. According to the obtained findings, an increase in the antioxidant activity of the Fennel extract was observed with increasing the concentration. Moreover, S. pyogenes and P. aeruginosa strains had the most and least level of tolerance to the methanolic extract of Fennel, respectively. On the other hand, anticancer activity of the extract was confirmed against A549 cancer cells. According to our findings, the methanolic extract has antibacterial, antioxidant and anticancer effects. Therefore, it can be applied to protect food from oxidative processes and microorganisms, causing contamination and intoxication. Moreover, it can be applied as a therapeutic target of cancer in the future. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Proceedings of the National Academy of Sciences India Section B Biological Sciences Springer Journals

Antibacterial and Antioxidant Activities and Anticancer Effects of Fennel Seeds (Foeniculum vulgare) Against Lung Cancer Cells

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Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to The National Academy of Sciences, India 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
0369-8211
eISSN
2250-1746
DOI
10.1007/s40011-022-01390-y
Publisher site
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Abstract

Natural anti-bacterial materials have received particular attention due to their higher food protection. The recent research was performed to evaluate the antioxidant, antimicrobial, and anticancer impacts of methanolic extract of Fennel (Foeniculum vulgare) seeds. To this aim, the methanolic extract was made following preparation of the Fennel seeds. The chemical compounds of the extract was determined using Gas–Liquid Chromatography-Mass Spectrometry. To evaluate the antioxidant impact of the methanolic extract of fennel, 2,2-diphenyl-1-picrylhydrazyl technique was applied for 7 concentrations of 200, 100, 50, 25, 22.5, 6.25 and 3 ppm. The antimicrobial impacts of the extract were evaluated using the inhibition zones process on isolates, including Streptococcus pyogenes, Streptococcus pneumonia, Klebsiella, pneumonia, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. In order to assess the anticancer activity of the extract in A549 cell line (Human lung cancer cell line), MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide-2-yl)-2,5-diphenyltetrazolium bromide assay) was done. According to the obtained findings, an increase in the antioxidant activity of the Fennel extract was observed with increasing the concentration. Moreover, S. pyogenes and P. aeruginosa strains had the most and least level of tolerance to the methanolic extract of Fennel, respectively. On the other hand, anticancer activity of the extract was confirmed against A549 cancer cells. According to our findings, the methanolic extract has antibacterial, antioxidant and anticancer effects. Therefore, it can be applied to protect food from oxidative processes and microorganisms, causing contamination and intoxication. Moreover, it can be applied as a therapeutic target of cancer in the future.

Journal

Proceedings of the National Academy of Sciences India Section B Biological Sciences – Springer Journals

Published: Jun 1, 2023

Keywords: Fennel; Antibacterial; Antioxidant; Anticancer

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