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- Publisher
- Springer Journals
- Copyright
- Copyright © 2013 by The National Academy of Sciences, India
- Subject
- Life Sciences; Life Sciences, general; Behavioural Sciences; Plant Biochemistry; Nucleic Acid Chemistry
- ISSN
- 0369-8211
- eISSN
- 2250-1746
- DOI
- 10.1007/s40011-013-0215-5
- Publisher site
- See Article on Publisher Site
Abstract
Experimental study was conducted to evaluate the antioxidant potential of sodium alginate coated probiotic Lactobacillus casei against chromium (VI)-induced oxidative stress in albino rats. Administration of chromium (Cr) VI significantly (p < 0.05) increased the peroxidation markers such as malondialdehyde and protein carbonyls along with significant (p < 0.05) decrease in antioxidant markers such as super oxide dismutase and reduced glutathione in liver and kidney homogenates. Chromium also caused a significant (p < 0.05) alteration in hepatic and renal functional markers in serum viz., total protein, alanine transaminase, blood urea nitrogen and creatinine. Prominent pathological changes observed in liver were vascular congestion, degenerative changes, dilatation of sinusoids and mononuclear cell infiltration, while the kidney showed degeneration of tubular epithelial cells, cystic dilatation of tubules and hyaline casts. Co-administration of coated probiotic L. casei strain 17 reversed the Cr-induced changes.
Journal
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences – Springer Journals
Published: Jul 23, 2013