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Antipsychotic Drug Doses and Adjunctive Drugs in the Outpatient Treatment of Schizophrenia

Antipsychotic Drug Doses and Adjunctive Drugs in the Outpatient Treatment of Schizophrenia This study investigated factors associated with the dose of antipsychotic medication prescribed at a schizophrenia unit outpatient clinic. The antipsychotic drug dose prescribed for 364 patients was converted to chlorpromazine equivalents (CPE) per day and concurrent prescriptions of lithium, carbamazepine, benzodiazepines, and antiparkinsonian drugs were recorded. We found that patients prescribed lithium, carbamazepine, and/or benzodiazepines as adjunctive drugs were receiving significantly higher doses of antipsychotic medication (p < 0.05). Patients prescribed both depot and oral neuroleptic drugs concurrently were receiving higher CPE-equivalent doses than those receiving either drug type alone (p < 0.05), and high-potency oral drugs were prescribed in higher CPE-equivalent doses than low-potency oral drugs (p < 0.05). Patients prescribed antiparkinsonian drgs were not receiving significantly higher CPE-equivalent doses of antipsychotic medication than patients not prescribed these drugs. There were no significant gender differences in the use of adjunctive drugs or in CPE-equivalent antipsychotic drug dose. Further research is needed to determine whether these findings are related to factors such as illness severity or to physician's prescribing practices. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Clinical Psychiatry Springer Journals

Antipsychotic Drug Doses and Adjunctive Drugs in the Outpatient Treatment of Schizophrenia

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Publisher
Springer Journals
Copyright
Copyright © 1997 by American Academy of Clinical Psychiatrists
Subject
Medicine & Public Health; Neurology; Psychiatry; Psychopharmacology
ISSN
1040-1237
eISSN
1573-3238
DOI
10.1023/A:1026249101457
Publisher site
See Article on Publisher Site

Abstract

This study investigated factors associated with the dose of antipsychotic medication prescribed at a schizophrenia unit outpatient clinic. The antipsychotic drug dose prescribed for 364 patients was converted to chlorpromazine equivalents (CPE) per day and concurrent prescriptions of lithium, carbamazepine, benzodiazepines, and antiparkinsonian drugs were recorded. We found that patients prescribed lithium, carbamazepine, and/or benzodiazepines as adjunctive drugs were receiving significantly higher doses of antipsychotic medication (p < 0.05). Patients prescribed both depot and oral neuroleptic drugs concurrently were receiving higher CPE-equivalent doses than those receiving either drug type alone (p < 0.05), and high-potency oral drugs were prescribed in higher CPE-equivalent doses than low-potency oral drugs (p < 0.05). Patients prescribed antiparkinsonian drgs were not receiving significantly higher CPE-equivalent doses of antipsychotic medication than patients not prescribed these drugs. There were no significant gender differences in the use of adjunctive drugs or in CPE-equivalent antipsychotic drug dose. Further research is needed to determine whether these findings are related to factors such as illness severity or to physician's prescribing practices.

Journal

Annals of Clinical Psychiatry – Springer Journals

Published: Sep 18, 2004

References

  • A longitudinal study of psychotropic prescriptions in a teaching nursing home
    Lantz, MS; Louis, A; Lowenstein, G; Kennedy, GJ
  • A review of the utilization of sedative-hypnotic drugs in a general hospital
    Picone, DA; D'Mello, DA; Foote, ML; Msibi, B.
  • Antidepressant side effects and physician prescribing patterns
    Huszonek, JJ; Dewan, MJ; Koss, M; Hardoby, WJ; Ispahani, A
  • Pharmacotherapy in out-patient psychiatric practice
    Olfson, M; Pincus, HA; Sabshin, M
  • Benzodiazepine utilization in a university hospital
    Zisselman, MH; Rovner, MD; Kelly, KG; Woods, C
  • Psychotropic drug prescribing in a general hospital inpatient psychiatric unit
    Brayley, J; Rafalowicz, E; Yellowlees, P
  • Factors predicting the use of multiple psychotropic medications
    Nichol, MB; Stimmel, GL; Lange, SC
  • Antidepressant prescription by British child psychiatrists: Practice and safety issues
    Bramble, DJ
  • Results of a brief survey on the prescribing practices for monoamine oxidase inhibitor antidepressants
    Clary, C; Mandos, LA; Schweizer, E
  • Psychotropic drug prescribing to chronic schizophrenics in a Hong Kong hospital
    Chiu, HFK; Shum, CW; Lam, CW
  • Hospital use of antipsychotic agents in 1989 and 1993: Stable dosing with decreased length of stay
    Baldessarini, RJ; Kando, JC; Centorrino, F
  • Antipsychotic drug doses in a schizophrenia inpatient unit
    Galletly, CA
  • Dissimilar dosing with high-potency and low-potency neuroleptics
    Baldessarini, RJ; Katz, B; Cotton, P
  • Significance of neuroleptic dose and plasma level in the pharmacological treatment of psychoses
    Baldessarini, RJ; Cohen, BM; Teicher, MH
  • Fluphenazine decanoate: a clinical problem?
    Inderbitzin, LB; Lewine, RRJ; Gloersen, BA; Rosen, PB; McDonald, SC; Vidanagama, BP
  • Changing patterns of antipsychotic dosages over a decade
    Reardon, GT; Rifkin, A; Schwartz, A; Myerson, A; Siris, SG
  • Pharmacoepidemiology in 136 hospitalized schizophrenic patients
    Zito, JM; Craig, TJ; Wanderling, J; Siegal, C
  • When symptoms persist: Choosing among alternative somatic treatments for schizophrenia
    Christison, GW; Kirch, DG; Wyatt, RJ
  • Adjunctive medication in the maintenance treatment of schizophrenia and its conceptual implications
    Siris, SG
  • Carbamazepine as an adjunct of antipsychotic therapy
    Dose, M; Apelt, S; Emrich, HM
  • Alprazolam as a antipsychotic adjunct in the emergency treatment of schizophrenia
    Barbee, JG; Mancuso, DM; Freed, CR; Todorov, AA
  • Treatments of Psychiatric Disorders: A Task Force Report of the American Psychiatric Association
  • Converting doses of fluphenazine decanoate to oral equivalents
    Brotman, AW; McCormick, S
  • Rapid tranquilization. A survey of emergency prescribing in a general psychiatric hospital
    Pilowsky, LS; Ring, H; Shine, PJ; Battersby, M; Lader, M