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Apoptosis: mechanisms and implications for cancer therapeutics

Apoptosis: mechanisms and implications for cancer therapeutics Apoptosis, or programmed cell death, is essential for many physiological and pathological processes. Apoptosis results from an orderly activation of several cysteine proteases called caspases, which can be classically triggered by two upstream pathways: the intrinsic and extrinsic pathways. Deregulation of apoptosis is essential for tumor growth and a hallmark of cancer cells. In the recent years, many key elements of the apoptotic process have been identified and have become strategic targets for anticancer therapy. The novel approaches that target the apoptotic pathway may have either a direct proapoptotic effect or alternatively may sensitize cancer cells to other cytotoxics. This review describes the major elements of the apoptotic process, with a special focus of the tight interactions between the extrinsic and intrinsic pathways, and summarizes some of the most promising implications for cancer therapeutics. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Targeted Oncology Springer Journals

Apoptosis: mechanisms and implications for cancer therapeutics

Mita, Monica; Mita, Alain; Tolcher, Anthony
Targeted Oncology , Volume 1 (4) – Oct 6, 2006
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References (247)

Publisher
Springer Journals
Copyright
Copyright © 2006 by Springer-Verlag
Subject
Medicine & Public Health; Biomedicine general; Oncology
ISSN
1776-2596
eISSN
1776-260X
DOI
10.1007/s11523-006-0034-1
Publisher site
See Article on Publisher Site

Abstract

Apoptosis, or programmed cell death, is essential for many physiological and pathological processes. Apoptosis results from an orderly activation of several cysteine proteases called caspases, which can be classically triggered by two upstream pathways: the intrinsic and extrinsic pathways. Deregulation of apoptosis is essential for tumor growth and a hallmark of cancer cells. In the recent years, many key elements of the apoptotic process have been identified and have become strategic targets for anticancer therapy. The novel approaches that target the apoptotic pathway may have either a direct proapoptotic effect or alternatively may sensitize cancer cells to other cytotoxics. This review describes the major elements of the apoptotic process, with a special focus of the tight interactions between the extrinsic and intrinsic pathways, and summarizes some of the most promising implications for cancer therapeutics.

Journal

Targeted Oncology – Springer Journals

Published: Oct 6, 2006

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