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Association studies in psychiatric genetics

Association studies in psychiatric genetics Molecular Psychiatry (1997) 2, 270–273 Ó 1997 Stockton Press All rights reserved 1359–4184/97 $12.00 GUEST EDITORIAL The term ‘allelic association’ was coined by Edwards ies with highly polymorphic microsatellite markers to describe lack of independence in a population suggest that associations can often be detected over dis- 5,6 between alleles at two closely linked loci. This simple tances of one megabase or more. This fits well with descriptive term was proposed to replace several terms fairly simple methods of estimating how long it takes such as linkage inequality, gametic disequilibrium and an association to decay. For example, the ‘half-life’ of linkage disequilibrium by which the phenomenon had an association between alleles at loci 1 cM apart is previously been described. The goal of allelic associ- about 69 generations or around 2000 years. ation studies of disease is to demonstrate a significantly Association studies have considerable theoretical different distribution of allelic variants in affected and appeal in the analysis of common diseases since they unaffected individuals. There are essentially three can detect genes that contribute only a relatively small possible explanations for this, two of which are scien- proportion of the overall liability of developing a dis- tifically interesting. The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Psychiatry Springer Journals

Association studies in psychiatric genetics

Molecular Psychiatry , Volume 2 (4) – Jul 1, 1997

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References (18)

Publisher
Springer Journals
Copyright
Copyright © Macmillan Publishers Limited 1997
Subject
Medicine & Public Health; Medicine/Public Health, general; Psychiatry; Neurosciences; Behavioral Sciences; Pharmacotherapy; Biological Psychology
ISSN
1359-4184
eISSN
1476-5578
DOI
10.1038/sj.mp.4000292
Publisher site
See Article on Publisher Site

Abstract

Molecular Psychiatry (1997) 2, 270–273 Ó 1997 Stockton Press All rights reserved 1359–4184/97 $12.00 GUEST EDITORIAL The term ‘allelic association’ was coined by Edwards ies with highly polymorphic microsatellite markers to describe lack of independence in a population suggest that associations can often be detected over dis- 5,6 between alleles at two closely linked loci. This simple tances of one megabase or more. This fits well with descriptive term was proposed to replace several terms fairly simple methods of estimating how long it takes such as linkage inequality, gametic disequilibrium and an association to decay. For example, the ‘half-life’ of linkage disequilibrium by which the phenomenon had an association between alleles at loci 1 cM apart is previously been described. The goal of allelic associ- about 69 generations or around 2000 years. ation studies of disease is to demonstrate a significantly Association studies have considerable theoretical different distribution of allelic variants in affected and appeal in the analysis of common diseases since they unaffected individuals. There are essentially three can detect genes that contribute only a relatively small possible explanations for this, two of which are scien- proportion of the overall liability of developing a dis- tifically interesting. The

Journal

Molecular PsychiatrySpringer Journals

Published: Jul 1, 1997

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