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Back to the drawing board

Back to the drawing board Virchows Arch (1998) 432:99–102 © Springer-Verlag 1998 REVIEW AR TICLE &roles:P.D. Lumb · L. Moore Intestinal neuronal dysplasia type B: not a histological entity yet &misc:Received: 15 October 1997 / Accepted: 12 November 1997 histopathological entity using the most widely recogni- Introduction sed criteria. Intestinal neuronal dysplasia of the submucous plexus (IND B) has been characterised by a group of clinical Methodological criticism features indistinguishable from those of Hirschsprung’s disease, including constipation, abdominal distension Comparing specimens which have been diagnosed histo- and enterocolitis [28]. The onset may be as early as the logically as IND B by virtue of the presence of giant first few days of life and it has been commonly associat- ganglia with normal controls will, of course, prove only ed with Hirschsprung’s disease, with which it has been that in all the IND B patients giant ganglia are present associated with a worse outcome [27, 39]. It has also and that in some of the normal controls they are not [17, been associated with phaeochromocytoma, medullary 18]. The larger the study, the more significant this result carcinoma of the thyroid, carcinoid tumour, cystic fibro- will seem. If this selection bias is unrecognised, there is sis http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Virchows Archiv Springer Journals

Back to the drawing board

Virchows Archiv , Volume 432 (2) – Feb 9, 1998

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References (33)

Publisher
Springer Journals
Copyright
Copyright © 1998 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Pathology
ISSN
0945-6317
eISSN
1432-2307
DOI
10.1007/s004280050140
Publisher site
See Article on Publisher Site

Abstract

Virchows Arch (1998) 432:99–102 © Springer-Verlag 1998 REVIEW AR TICLE &roles:P.D. Lumb · L. Moore Intestinal neuronal dysplasia type B: not a histological entity yet &misc:Received: 15 October 1997 / Accepted: 12 November 1997 histopathological entity using the most widely recogni- Introduction sed criteria. Intestinal neuronal dysplasia of the submucous plexus (IND B) has been characterised by a group of clinical Methodological criticism features indistinguishable from those of Hirschsprung’s disease, including constipation, abdominal distension Comparing specimens which have been diagnosed histo- and enterocolitis [28]. The onset may be as early as the logically as IND B by virtue of the presence of giant first few days of life and it has been commonly associat- ganglia with normal controls will, of course, prove only ed with Hirschsprung’s disease, with which it has been that in all the IND B patients giant ganglia are present associated with a worse outcome [27, 39]. It has also and that in some of the normal controls they are not [17, been associated with phaeochromocytoma, medullary 18]. The larger the study, the more significant this result carcinoma of the thyroid, carcinoid tumour, cystic fibro- will seem. If this selection bias is unrecognised, there is sis

Journal

Virchows ArchivSpringer Journals

Published: Feb 9, 1998

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