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/lp/springer-journals/bone-mineral-density-of-the-ultra-distal-radius-are-we-ignoring-v2W6Z06OrK
- Publisher
- Springer Journals
- Copyright
- Copyright © International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
- ISSN
- 1862-3522
- eISSN
- 1862-3514
- DOI
- 10.1007/s11657-023-01218-w
- Publisher site
- See Article on Publisher Site
Abstract
SummaryThe current study explored the possible utilization in dual-X-ray-absorptiometry scanning (DXA) of the ultra-distal radius (UDR). This region of interest is currently unused and mostly unstudied in this context. The study findings suggest UDR as potential useful region of interest in DXA scanning and warrant further study of the site.PurposeBone mineral density (BMD) measurement of a non-dominant arm is not routinely performed during dual-X-ray-absorptiometry (DXA) test, and the possible utility of ultra-distal (UDR) radius BMD is not well-studied. We evaluated in women, correlations of UDR BMD with fracture prevalence, fracture risk prediction by the fracture risk assessment tool (FRAX), and osteoporosis diagnosed by traditional sites.MethodsWomen who underwent a routine DXA (including their non-dominant forearm and including UDR BMD) in a tertiary medical center were included. Risk factors relevant to FRAX calculation were assessed via a self-administered questionnaire. Spearman correlations of UDR BMD to 10-year risks of major osteoporotic and hip fractures (assessed by FRAX) were explored. The possible added value of UDR BMD in explaining prevalent osteoporotic fractures was assessed using a multivariable regression model incorporating age and traditional osteoporosis diagnosis.ResultsThe study included 1245 women with a median age of 66 years (interquartile range: 59–73), of whom 298 (24%) had UDR T-score ≤ − 2.5 and 154 (12%) reported prior fractures. UDR BMD was significantly negatively correlated with FRAX risk score for hip and major osteoporotic fractures (R = − 0.5 and R = − 0.41, respectively; P < 0.001). UDR T-score ≤ − 2.5 was associated with higher fracture prevalence (19% vs 10%; P < 0.001) and remained significant after adjusting for traditional BMD and age (OR 1.49, 1.01–2.19; P = 0.043).ConclusionUDR BMD correlates both with prior fractures and with predicted fracture risks and might pose added value over traditional DXA sites.
Journal
Archives of Osteoporosis – Springer Journals
Published: Feb 2, 2023
Keywords: Bone mineral density; Ultra-distal radius; Osteoporosis; FRAX