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Brain-Computer Interface ResearchA Minimally Invasive Endovascular Stent-Electrode Array for Chronic Recordings of Cortical Neural Activity

Brain-Computer Interface Research: A Minimally Invasive Endovascular Stent-Electrode Array for... [Intracranial electrode arrays for recording and stimulating electrical brain activity have facilitated major advances in the treatment of neurological conditions over the past decade. When compared to scalp electroencephalography (EEG), cortical recordings have demonstrated superior spatial resolution and consequently a greater potential for cognitive command output. Traditional cortical arrays require direct implantation into the brain via open craniotomy, which is a delicate and lengthy procedure. This can lead to inflammatory tissue responses amongst other clinical complications and has necessitated the development of minimally invasive methods that circumvent or mitigate brain trauma. In this study, we demonstrate the feasibility of chronically recording brain activity from within an external cerebral vein using a passive stent - electrode recording array (stentrode). We achieved implantation into a superficial cortical vein lying adjacent to the motor cortex using catheter angiography. Access was made via vascular puncture in the external jugular vein in the neck. Following successful implantation, we demonstrated neural recordings in freely moving sheep for time periods up to 190 days. Venous internal lumen patency was preserved for the duration of implantation. Spectral content and bandwidth of vascular electrocorticography were found to be comparable to those of recordings from epidural surface arrays.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Brain-Computer Interface ResearchA Minimally Invasive Endovascular Stent-Electrode Array for Chronic Recordings of Cortical Neural Activity

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Publisher
Springer International Publishing
Copyright
© The Author(s) 2017
ISBN
978-3-319-64372-4
Pages
55 –63
DOI
10.1007/978-3-319-64373-1_6
Publisher site
See Chapter on Publisher Site

Abstract

[Intracranial electrode arrays for recording and stimulating electrical brain activity have facilitated major advances in the treatment of neurological conditions over the past decade. When compared to scalp electroencephalography (EEG), cortical recordings have demonstrated superior spatial resolution and consequently a greater potential for cognitive command output. Traditional cortical arrays require direct implantation into the brain via open craniotomy, which is a delicate and lengthy procedure. This can lead to inflammatory tissue responses amongst other clinical complications and has necessitated the development of minimally invasive methods that circumvent or mitigate brain trauma. In this study, we demonstrate the feasibility of chronically recording brain activity from within an external cerebral vein using a passive stent - electrode recording array (stentrode). We achieved implantation into a superficial cortical vein lying adjacent to the motor cortex using catheter angiography. Access was made via vascular puncture in the external jugular vein in the neck. Following successful implantation, we demonstrated neural recordings in freely moving sheep for time periods up to 190 days. Venous internal lumen patency was preserved for the duration of implantation. Spectral content and bandwidth of vascular electrocorticography were found to be comparable to those of recordings from epidural surface arrays.]

Published: Aug 22, 2017

Keywords: Brain computer interface (BCI); Brain machine interface (BMI); Endovascular; Electrocorticography (ECoG)

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