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Bupropion Treatment of Serotonin Reuptake Antidepressant-Associated Sexual Dysfunction

Bupropion Treatment of Serotonin Reuptake Antidepressant-Associated Sexual Dysfunction Annals of Clinical Psychiatry, Vol. 9, No. 4, 1997 Bupropion Treatment of Serotonin Reuptake Antidepressant-Associated Sexual Dysfunction Lawrence A. Labbate, M.D.,1,4 Jamie B. Grimes, M.D.,2 Alan Hines, M.D.,2 and Mark H. Pollack, M.D.3 Serotonin reuptake inhibitor (SRI)-induced sexual dysfunction is common, and a number of pharmacologic adjunctive strategies have been employed to treat this vexing problem. This open label study tested the efficacy of adjunctive bupropion across several measures of sexual function. Patients taking SRIs for various mood or anxiety disorders who reported prospec- tive decline in sexual function after at least 2 months on SRIs were offered treatment with bupropion, 75 mg/day. Eight patients were treated, and sexual function was measured by use of a visual analog scale at 1 month of treatment. Four of eight patients experienced marked improvement in sexual dysfunction following adjunctive bupropion treatment. Bupropion may be a pharmacologic option for treating SRI-associated sexual dysfunction, though controlled clinical trials are needed. KEY WORDS: Bupropion; antidepressants; sexual dysfunction; serotonin; depression. INTRODUCTION A number of strategies have been employed to counter SRI-induced sexual dysfunction. Clinical Antidepressant-induced sexual dysfunction is a strategies have included adding agents such as cypro- common adverse effect. Sexual dysfunction may oc- heptadine (8,9) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Clinical Psychiatry Springer Journals

Bupropion Treatment of Serotonin Reuptake Antidepressant-Associated Sexual Dysfunction

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Publisher
Springer Journals
Copyright
Copyright © 1997 by American Academy of Clinical Psychiatrists
Subject
Medicine & Public Health; Neurology; Psychiatry; Psychopharmacology
ISSN
1040-1237
eISSN
1573-3238
DOI
10.1023/A:1022356427242
Publisher site
See Article on Publisher Site

Abstract

Annals of Clinical Psychiatry, Vol. 9, No. 4, 1997 Bupropion Treatment of Serotonin Reuptake Antidepressant-Associated Sexual Dysfunction Lawrence A. Labbate, M.D.,1,4 Jamie B. Grimes, M.D.,2 Alan Hines, M.D.,2 and Mark H. Pollack, M.D.3 Serotonin reuptake inhibitor (SRI)-induced sexual dysfunction is common, and a number of pharmacologic adjunctive strategies have been employed to treat this vexing problem. This open label study tested the efficacy of adjunctive bupropion across several measures of sexual function. Patients taking SRIs for various mood or anxiety disorders who reported prospec- tive decline in sexual function after at least 2 months on SRIs were offered treatment with bupropion, 75 mg/day. Eight patients were treated, and sexual function was measured by use of a visual analog scale at 1 month of treatment. Four of eight patients experienced marked improvement in sexual dysfunction following adjunctive bupropion treatment. Bupropion may be a pharmacologic option for treating SRI-associated sexual dysfunction, though controlled clinical trials are needed. KEY WORDS: Bupropion; antidepressants; sexual dysfunction; serotonin; depression. INTRODUCTION A number of strategies have been employed to counter SRI-induced sexual dysfunction. Clinical Antidepressant-induced sexual dysfunction is a strategies have included adding agents such as cypro- common adverse effect. Sexual dysfunction may oc- heptadine (8,9)

Journal

Annals of Clinical Psychiatry – Springer Journals

Published: Sep 18, 2004

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