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Camphor Toxicity: A Review of Recent Findings

Camphor Toxicity: A Review of Recent Findings Camphor (CMP), a white crystalline compound naturally produced from the bark of Cinnamomum camphora L. trees, is a key constituent in modern day home remedies, one of which is its use as a carminative agent. It is a plant product that is used therapeutically as one of the components of herbal infusions in the treatment of back pain and pile. In Nigeria, these CMP-containing herbal infusions are abusively taken by men as aphrodisiac to last long during sexual intercourse. CMP has been reported to possess cough suppressant, nasal decongestant, counterirritant, and antipruritic properties. Because of all these properties, the abusive use, unintentional or accidental CMP poisonings in humans, mostly children, have led to symptoms including seizures, irritability, confusion, stomach upset, and some other central nervous-related disorders. CMP toxicities have also been reported at high doses in rats, including tissue (liver, kidney, lung, and testis) oxidative stress; histopathological disorders in two brain compartments including cerebral cortex and hippocampus, liver, lung, and kidney; male reproductive and thyroid hormones disruptions; and upregulation of tissue (brain, testis, lung, liver, and kidney) inflammatory chemokines and cytokines via nuclear factor-kappa B activation. This review briefly looked at the reported toxicological outcomes of CMP exposure, with special emphasis on my contributions to CMP toxicity studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Proceedings of the National Academy of Sciences India Section B Biological Sciences Springer Journals

Camphor Toxicity: A Review of Recent Findings

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References (26)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to The National Academy of Sciences, India 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
0369-8211
eISSN
2250-1746
DOI
10.1007/s40011-022-01437-0
Publisher site
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Abstract

Camphor (CMP), a white crystalline compound naturally produced from the bark of Cinnamomum camphora L. trees, is a key constituent in modern day home remedies, one of which is its use as a carminative agent. It is a plant product that is used therapeutically as one of the components of herbal infusions in the treatment of back pain and pile. In Nigeria, these CMP-containing herbal infusions are abusively taken by men as aphrodisiac to last long during sexual intercourse. CMP has been reported to possess cough suppressant, nasal decongestant, counterirritant, and antipruritic properties. Because of all these properties, the abusive use, unintentional or accidental CMP poisonings in humans, mostly children, have led to symptoms including seizures, irritability, confusion, stomach upset, and some other central nervous-related disorders. CMP toxicities have also been reported at high doses in rats, including tissue (liver, kidney, lung, and testis) oxidative stress; histopathological disorders in two brain compartments including cerebral cortex and hippocampus, liver, lung, and kidney; male reproductive and thyroid hormones disruptions; and upregulation of tissue (brain, testis, lung, liver, and kidney) inflammatory chemokines and cytokines via nuclear factor-kappa B activation. This review briefly looked at the reported toxicological outcomes of CMP exposure, with special emphasis on my contributions to CMP toxicity studies.

Journal

Proceedings of the National Academy of Sciences India Section B Biological Sciences – Springer Journals

Published: Dec 1, 2023

Keywords: Camphor; Tissue toxicity; Histopathological disorders; Rats

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