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Cell biology: The importance of the endosome in intracellular traffic

Cell biology: The importance of the endosome in intracellular traffic ~M~4-------------------------------------~N~E~WV<S~ANN~D~VmiE~WS----------------------NA_ru_R_E __ v_o_L_~ __ 2s_A_u_c;u_~~~~~3 part of the same intracellular proces.sing CeU biology system. The idea that a distinctive cytoplasmic compartment exists for the processing of The importance of the endosome internalized ligand-receptor complexes is, of course, not new (see, for example, refs in intracellular traffic 13 and 14), but until very recently it was based largely on the identification of endo­ from Colin R. Hopkins cytosed ligands by electron microscopy. IN recent years it has become clear that all is that of epidermal growth factor , but However, in recent cell-fractionation animal cells have a common mechanism for many other instances have also been studies on a variety of cell types, a cyto­ internalizing different ligands bound to the described. The route from the plasma plasmic compartment with a characteristic specialized receptors on their surfaces. The membrane to the lysosome is clearly a well buoyant density and highly enriched in en­ 15 19 fate of both receptor and ligand once they beaten path; now, as different classes of docytosed receptors has been isolated - • have entered the cell can, however, vary bet­ receptor are being studied in the same cell, Components within the receptor-rich frac­ ween one http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Cell biology: The importance of the endosome in intracellular traffic

Nature , Volume 304 (5928) – Aug 1, 1983

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References (32)

Publisher
Springer Journals
Copyright
Copyright © 1983 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/304684a0
Publisher site
See Article on Publisher Site

Abstract

~M~4-------------------------------------~N~E~WV<S~ANN~D~VmiE~WS----------------------NA_ru_R_E __ v_o_L_~ __ 2s_A_u_c;u_~~~~~3 part of the same intracellular proces.sing CeU biology system. The idea that a distinctive cytoplasmic compartment exists for the processing of The importance of the endosome internalized ligand-receptor complexes is, of course, not new (see, for example, refs in intracellular traffic 13 and 14), but until very recently it was based largely on the identification of endo­ from Colin R. Hopkins cytosed ligands by electron microscopy. IN recent years it has become clear that all is that of epidermal growth factor , but However, in recent cell-fractionation animal cells have a common mechanism for many other instances have also been studies on a variety of cell types, a cyto­ internalizing different ligands bound to the described. The route from the plasma plasmic compartment with a characteristic specialized receptors on their surfaces. The membrane to the lysosome is clearly a well buoyant density and highly enriched in en­ 15 19 fate of both receptor and ligand once they beaten path; now, as different classes of docytosed receptors has been isolated - • have entered the cell can, however, vary bet­ receptor are being studied in the same cell, Components within the receptor-rich frac­ ween one

Journal

NatureSpringer Journals

Published: Aug 1, 1983

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