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Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro

Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro Acetylcholine is vital for cognitive functions of the brain. Although its actions in the individual cell are known in some detail 1 , its effects at the network level are poorly understood 2 . The hippocampus, which receives a major cholinergic input from the medial septum/diagonal band 3 , is important in memory 4 , 5 and exhibits network activity at 40 Hz during relevant behaviours 6 . Here we show that cholinergic activation is sufficient to induce 40-Hz network oscillations 7 in the hippocampus in vitro. Oscillatory activity is generated spontaneously in the CA3 subfield and can persist for hours. During the oscillatory state, principal neurons fire action potentials that are phase-related to the extracellular oscillation, but each neuron fires in only a small proportion of the cycles. Both excitatory and inhibitory synaptic events participate during the network oscillation in a precise temporal pattern. These results indicate that subcortical cholinergic input can control hippocampal memory processing by inducing fast network oscillations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro

Nature , Volume 394 (6689) – Dec 30, 1998

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References (32)

Publisher
Springer Journals
Copyright
Copyright © 1998 by Macmillan Magazines Ltd.
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/28179
Publisher site
See Article on Publisher Site

Abstract

Acetylcholine is vital for cognitive functions of the brain. Although its actions in the individual cell are known in some detail 1 , its effects at the network level are poorly understood 2 . The hippocampus, which receives a major cholinergic input from the medial septum/diagonal band 3 , is important in memory 4 , 5 and exhibits network activity at 40 Hz during relevant behaviours 6 . Here we show that cholinergic activation is sufficient to induce 40-Hz network oscillations 7 in the hippocampus in vitro. Oscillatory activity is generated spontaneously in the CA3 subfield and can persist for hours. During the oscillatory state, principal neurons fire action potentials that are phase-related to the extracellular oscillation, but each neuron fires in only a small proportion of the cycles. Both excitatory and inhibitory synaptic events participate during the network oscillation in a precise temporal pattern. These results indicate that subcortical cholinergic input can control hippocampal memory processing by inducing fast network oscillations.

Journal

NatureSpringer Journals

Published: Dec 30, 1998

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