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Co-association of CD3ζ with a receptor (CD16) for IgG Fc on human natural killer cells

Co-association of CD3ζ with a receptor (CD16) for IgG Fc on human natural killer cells NATURAL killer (NK) cells are a subset of lymphocytes that mediate major histocompatibility complex (MHC)-nonrestricted cytotoxicity against tumours and virus-infected cells and secrete numerous cytokines on activation1. NK cells are distinct from mature T lymphocytes, because they do not rearrange or productively transcribe T-cell receptor α-, β-, γ- or δ-chain genes and do not express the CD3 γ- or δ-subunits2–6. But recent studies indicate that NK cells do express CD3ζ, co-associated with other membrane proteins7. Here we report that CD16, the receptor for the Fc (constant) region of IgG, specifically associates with the CD3ζ homodimer on the membrane of human NK cells, and that co-transfection with CD3ζ complementary DNA permits expression of a transmembrane-linked CD 16 complex on COS-7 cells. These findings indicate that CD3ζ can co-associate with membrane receptors of diverse ceil types and function as a common structure for signal transduction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Co-association of CD3ζ with a receptor (CD16) for IgG Fc on human natural killer cells

Nature , Volume 342 (6251) – Dec 14, 1989

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References (35)

Publisher
Springer Journals
Copyright
Copyright © 1989 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/342803a0
Publisher site
See Article on Publisher Site

Abstract

NATURAL killer (NK) cells are a subset of lymphocytes that mediate major histocompatibility complex (MHC)-nonrestricted cytotoxicity against tumours and virus-infected cells and secrete numerous cytokines on activation1. NK cells are distinct from mature T lymphocytes, because they do not rearrange or productively transcribe T-cell receptor α-, β-, γ- or δ-chain genes and do not express the CD3 γ- or δ-subunits2–6. But recent studies indicate that NK cells do express CD3ζ, co-associated with other membrane proteins7. Here we report that CD16, the receptor for the Fc (constant) region of IgG, specifically associates with the CD3ζ homodimer on the membrane of human NK cells, and that co-transfection with CD3ζ complementary DNA permits expression of a transmembrane-linked CD 16 complex on COS-7 cells. These findings indicate that CD3ζ can co-associate with membrane receptors of diverse ceil types and function as a common structure for signal transduction.

Journal

NatureSpringer Journals

Published: Dec 14, 1989

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