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Control of Surface Wrinkles on Shape Memory PLA/PPDO Micro-nanofibers and Their Applications in Drug Release and Anti-scarring

Control of Surface Wrinkles on Shape Memory PLA/PPDO Micro-nanofibers and Their Applications in... Micro- and nano-fibers of shape memory polymers (SMP) offer multiple advantages like high specific surface area, porosity, and intelligence, and are suitable for biomedical applications. In this study, biodegradable poly (p-dioxanone) (PPDO) materials were incorporated to improve the brittleness of shape memory polylactic acid (PLA), and plasticizers were used to reduce the transition temperature of SMP composites such that their transitions could be induced close to body temperature. Furthermore, an electrostatic spinning technology was applied to prepare SMP fibers with wrinkled structures and regulate their microstructures and morphologies such that the intelligent transition of wrinkled and smooth morphologies can be achieved on the fiber surface. The application of this controllable-morphology fiber membrane in intelligent controlled drug release and scar inhibition after Ahmed Glaucoma Valve (AGV) implantation was also studied. The drug release from the stretched and deformed drug-loaded fiber membranes was faster than those from membranes with the original shape. This membrane with micro- and nano-fibers had good anti-scarring effects that improved after drug loading. The achievement of intelligent controlled drug release and the evident anti-scarring effects of the membrane broaden the application of SMP fibers in the biomedical field.Graphical Abstract[graphic not available: see fulltext] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Fiber Materials Springer Journals

Control of Surface Wrinkles on Shape Memory PLA/PPDO Micro-nanofibers and Their Applications in Drug Release and Anti-scarring

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Publisher
Springer Journals
Copyright
Copyright © Donghua University, Shanghai, China 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
2524-7921
eISSN
2524-793X
DOI
10.1007/s42765-022-00249-1
Publisher site
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Abstract

Micro- and nano-fibers of shape memory polymers (SMP) offer multiple advantages like high specific surface area, porosity, and intelligence, and are suitable for biomedical applications. In this study, biodegradable poly (p-dioxanone) (PPDO) materials were incorporated to improve the brittleness of shape memory polylactic acid (PLA), and plasticizers were used to reduce the transition temperature of SMP composites such that their transitions could be induced close to body temperature. Furthermore, an electrostatic spinning technology was applied to prepare SMP fibers with wrinkled structures and regulate their microstructures and morphologies such that the intelligent transition of wrinkled and smooth morphologies can be achieved on the fiber surface. The application of this controllable-morphology fiber membrane in intelligent controlled drug release and scar inhibition after Ahmed Glaucoma Valve (AGV) implantation was also studied. The drug release from the stretched and deformed drug-loaded fiber membranes was faster than those from membranes with the original shape. This membrane with micro- and nano-fibers had good anti-scarring effects that improved after drug loading. The achievement of intelligent controlled drug release and the evident anti-scarring effects of the membrane broaden the application of SMP fibers in the biomedical field.Graphical Abstract[graphic not available: see fulltext]

Journal

Advanced Fiber Materials – Springer Journals

Published: Apr 1, 2023

Keywords: Shape memory polymers; Micro-nano fibers; Wrinkled structure; Smart controlled release of drugs; Anti-scarring

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