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A. Guerra, F. Alves, K. Maes, S. Joniau, J. Cassis, R. Maio, M. Cravo, H. Mouriño (2022)
Early biomarkers of extracapsular extension of prostate cancer using MRI-derived semantic featuresCancer Imaging, 22
– The study participants included 185 patients who Incorrect had undergone RARP at our institution, 26% of whom were pECE + (i.e., pECE positive). Significant – The study participants included 184 patients who had predictors of pECE + were TCCL, capsular disrup- undergone RARP at our institution, 26% of whom tion, measurable ECE on MRI, and a GS of ≥ 7(4 + 3) were pECE + (i.e., pECE positive). Significant pre - on a prostate biopsy. The original article can be found online at https:// doi. org/ 10. 1186/ s40644- Materials and methods 022- 00509-8. Incorrect *Correspondence: Adalgisa Guerra – This study included 257 participants, all of whom gisaguerra@gmail.com were patients diagnosed with PCa between 2015 and Radiology Department, Hospital da Luz Lisboa, Avenida Lusíada, N° 100, 1500-650 Lisbon, Portugal Faculty of Medicine, Clinical Research CIBIT/ ICNAS, University – The exclusion criteria (Fig. 1) led to 72 patients being of Coimbra, 3000-548 Coimbra, Portugal excluded, leaving only 185 patients for analysis. Urology Department, Hospital da Luz Lisboa, Avenida Lusíada, N° 100, 1500-650 Lisbon, Portugal Urology Department, University Hospitals Leuven, UZ Leuven Correct Gasthuisberg Campus, Urology, Herestraat 49, 3000 Leuven, Belgium Pathology Department, Hospital da Luz Lisboa, Avenida Lusíada, N° 100, 1500-650 Lisbon, Portugal – This study included 237 participants, all of whom Nova Medical School-Nova University of Lisbon, Portugal e Hospital da were patients diagnosed with PCa between 2015 and Luz Lisboa, Campo Mártires da Pátria, N° 130, 1169-056 Lisbon, Portugal Gastroenterology Department- Hospital da Luz Lisboa, Avenida Lusíada, N° 100, 1500-650 Lisbon, Portugal – The exclusion criteria (Fig. 1) led to 52 patients being Centro de Estatística E Aplicações, Departamento de Estatística E excluded, leaving only 185 patients for analysis. Investigação Operacional, Faculdade de Ciências, Universidade de Lisboa, Edifício C6 – Piso 4, Campo Grande, 1749 – 016 Lisbon, Portugal © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/. The Creative Commons Public Domain Dedication waiver (http:// creat iveco mmons. org/ publi cdoma in/ zero/1. 0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Guerra et al. Cancer Imaging (2023) 23:32 Page 2 of 2 Results Figure 4 caption Incorrect Incorrect – For every increase of one millimeter in the cap- – Gleason score less aggressive: < 7(3 + 4) sular contact length, the odds of presenting pECE + increases by 9% compared with patients with Correct no contact capsular length. – Gleason score less aggressive: < 7 (4 + 3) Correct – For every increase of one millimeter in the cap- sular contact length, the odds of presenting pECE + increases by 9.7% compared with patients with no contact capsular length. Incorrect – The odds of presenting pECE + were 3.3, 5.5, and Reference 1. Guerra A, et al. Early biomarkers of extracapsular extension of prostate 6.2 times higher in patients with capsular disrup- cancer using MRI-derived semantic features. Cancer Imaging. 2022;22:74. tion, measurable ECE on MRI, and a GSs of ≥ (4 + 3), https:// doi. org/ 10. 1186/ s40644- 022- 00509-8. respectively, compared to patients without these characteristics. Correct – The odds of presenting pECE + were 3.0, 5.2, and 6.2 times higher in patients with capsular disrup- tion, measurable ECE on MRI, and a GSs of ≥ (4 + 3), respectively, compared to patients without these characteristics. Incorrect – To evaluate the performance of the multivariable logistic regression model, we computed the ROC curve and the AUC. The estimated model shows a good performance in distinguishing pECE + patients from pECE − patients, with an AUC of 0.90 (86.0– 95.8%), a high sensitivity (93%), and moderate speci- ficity (70%) (Table 3). Correct Re Read ady y to to submit y submit your our re researc search h ? Choose BMC and benefit fr ? Choose BMC and benefit from om: : – To evaluate the performance of the multivariable fast, convenient online submission logistic regression model, we computed the ROC thorough peer review by experienced researchers in your field curve and the AUC. The estimated model shows a rapid publication on acceptance good performance in distinguishing pECE + patients support for research data, including large and complex data types from pECE − patients, with an AUC of 0.91 (85.3– • gold Open Access which fosters wider collaboration and increased citations 94.5%), a high sensitivity (86%), and moderate speci- maximum visibility for your research: over 100M website views per year ficity (78%) (Table 3). At BMC, research is always in progress. Learn more biomedcentral.com/submissions
Cancer Imaging – Springer Journals
Published: Apr 3, 2023
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