Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

d-Lactate and intestinal fatty acid-binding protein are elevated in serum in patients with acute ischemic stroke

d-Lactate and intestinal fatty acid-binding protein are elevated in serum in patients with acute... Experimental studies suggest that the intestinal barrier is affected in ischemic stroke. d-Lactate and intestinal fatty acid-binding protein (IFABP) are markers of intestinal mucosa integrity and barrier function. Our purpose was to evaluate the serum concentrations of these markers in patients with acute ischemic stroke (AIS). We included patients with AIS and used healthy subjects as controls. Clinical, demographic and outcome measures were recorded. Blood was drawn within 24 h of symptom onset. Serum concentrations of d-Lactate and IFABP were determined using commercially available colorimetric and ELISA kits, respectively. We included a total of 61 patients (median age of 64 years). The majority of patients were male (57.4%). The most common cause of stroke was atherosclerosis (34.4%), followed by small-vessel disease and cardioembolic (32.7% each). Mean admission NIHSS score was 8. Median IFABP and d-Lactate concentrations were significantly higher in patients than in controls. Concentrations were not associated with stroke severity or 3-month outcome. Patients with large-artery atherosclerosis and cardioembolic etiology had higher d-Lactate values than patients with small-vessel disease. d-Lactate and IFABP were significantly elevated in patients with AIS. This suggests that there is disruption of the intestinal barrier in patients with AIS. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Neurologica Belgica Springer Journals

d-Lactate and intestinal fatty acid-binding protein are elevated in serum in patients with acute ischemic stroke

Download PDF
7 pages

Loading next page...
 
/lp/springer-journals/d-lactate-and-intestinal-fatty-acid-binding-protein-are-elevated-in-PlDz6sdIfL
Publisher
Springer Journals
Copyright
Copyright © Belgian Neurological Society 2018
Subject
Biomedicine; Neurosciences; Neurology; Neuroradiology; Medicine/Public Health, general
ISSN
0300-9009
eISSN
2240-2993
DOI
10.1007/s13760-018-0940-x
Publisher site
See Article on Publisher Site

Abstract

Experimental studies suggest that the intestinal barrier is affected in ischemic stroke. d-Lactate and intestinal fatty acid-binding protein (IFABP) are markers of intestinal mucosa integrity and barrier function. Our purpose was to evaluate the serum concentrations of these markers in patients with acute ischemic stroke (AIS). We included patients with AIS and used healthy subjects as controls. Clinical, demographic and outcome measures were recorded. Blood was drawn within 24 h of symptom onset. Serum concentrations of d-Lactate and IFABP were determined using commercially available colorimetric and ELISA kits, respectively. We included a total of 61 patients (median age of 64 years). The majority of patients were male (57.4%). The most common cause of stroke was atherosclerosis (34.4%), followed by small-vessel disease and cardioembolic (32.7% each). Mean admission NIHSS score was 8. Median IFABP and d-Lactate concentrations were significantly higher in patients than in controls. Concentrations were not associated with stroke severity or 3-month outcome. Patients with large-artery atherosclerosis and cardioembolic etiology had higher d-Lactate values than patients with small-vessel disease. d-Lactate and IFABP were significantly elevated in patients with AIS. This suggests that there is disruption of the intestinal barrier in patients with AIS.

Journal

Acta Neurologica Belgica – Springer Journals

Published: May 21, 2018

References

  • Heart disease and stroke statistics—2013 update: a report from the American Heart Association
    Go, AS; Mozaffarian, D; Roger, VL
  • Lifetime cost of stroke in the United States
    Taylor, TN; Davis, PH; Torner, JC
  • Gastrointestinal complications after ischemic stroke
    Camara-Lemarroy, CR; Ibarra-Yruegas, BE; Gongora-Rivera, F
  • Bacterial translocation in experimental stroke: what happens to the gut barrier?
    Tascilar, N; Irkorucu, O; Tascilar, O
  • Colonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome
    Caso, JR; Hurtado, O; Pereira, MP
  • Current status on plasma biomarkers for acute mesenteric ischemia
    Acosta, S; Nilsson, T
  • Beyond lactate: is there a role for serum lactate measurement in diagnosing acute mesenteric ischemia?
    Demir, IE; Ceyhan, GO; Friess, H
  • Functional changes of intestinal mucosal barrier in surgically critical patients
    Guo, YY; Liu, ML; He, XD
  • Human intestinal fatty acid binding protein: report of an assay with studies in normal volunteers and intestinal ischemia
    Lieberman, JM; Sacchettini, J; Marks, C
  • d-Lactate in human and ruminant metabolism
    Ewaschuk, JB; Naylor, JM; Zello, GA
  • Enterocyte fatty acid-binding proteins (FABPs): different functions of liver and intestinal FABPs in the intestine
    Gajda, AM; Storch, J
  • Serum D()-lactate levels as an aid to diagnosing acute intestinal ischemia
    Murray, MJ; Gonze, MD; Nowak, LR
  • Can serum l-lactate, d-Lactate, creatine kinase and I-FABP be used as diagnostic markers in critically ill patients suspected for bowel ischemia
    Voort, PH; Westra, B; Wester, JP
  • Plasma d-Lactate as a potential early marker for colon ischaemia after open aortic reconstruction
    Assadian, A; Assadian, O; Senekowitsch, C
  • Circulating intestinal fatty acid-binding protein as an early marker of intestinal necrosis after aortic surgery: a prospective observational cohort study
    Vermeulen Windsant, IC; Hellenthal, FA; Derikx, JP
  • Intestinal mucosal injury in critically ill surgical patients: preliminary observations
    Gollin, G; Zieg, PM; Cohn, SM
  • Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice
    Crapser, J; Ritzel, R; Verma, R
  • Translocation and dissemination of commensal bacteria in post-stroke infection
    Stanley, D; Mason, LJ; Mackin, KE
  • Role of the gut in multiple organ failure: bacterial translocation and permeability changes
    Swank, GM; Deitch, EA
  • Review article: bacterial translocation in the critically ill—evidence and methods of prevention
    Gatt, M; Reddy, BS; MacFie, J
  • Prevalence of subdiaphragmatic visceral infarction in cardioembolic stroke
    Slaoui, T; Klein, IF; Guidoux, C
  • Prevalence and determinants of subdiaphragmatic visceral infarction in patients with fatal stroke
    Abboud, H; Labreuche, J; Gongora-Riverra, F
  • The heart and the gut
    Rogler, G; Rosano, G