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Delineation of Target Volume for Radiotherapy of High-Grade Gliomas by 99mTc-MIBI SPECT and MRI Fusion

Delineation of Target Volume for Radiotherapy of High-Grade Gliomas by 99mTc-MIBI SPECT and MRI... Strahlentherapie und Onkologie Original Article Delineation of Target Volume for Radiotherapy of High- 99m Grade Gliomas by Tc-MIBI SPECT and MRI Fusion 1 2 3 1 1 Marco Krengli , Gianfranco Loi , Gianmauro Sacchetti , Irene Manfredda , Giuseppina Gambaro , 2 4 3 Marco Brambilla , Alessandro Carriero , Eugenio Inglese Background and Purpose: Computed tomography (CT) and magnetic resonance imaging (MRI) are traditionally used for treat- 99m ment planning of high-grade glioma. Tc-methoxy-isobutyl-isonitrile (MIBI) single-photon emission computed tomography (SPECT) showed high sensitivity and specificity in literature series. In the present study, it was investigated how the information 99m provided by Tc-MIBI SPECT and MRI fusion could affect target delineation for radiotherapy of high-grade glioma. 99m Patients and Methods: 21 patients with high-grade glioma were studied by MRI and Tc-MIBI SPECT imaging. The gross tumor volume (GTV) was outlined on MRI (MRI-GTV) and SPECT images (SPECT-GTV). Three additional volumes were analyzed: the (MRI+SPECT)-GTV representing the whole amount of MRI-GTV plus SPECT-GTV, the (MRI&SPECT)-GTV identified by the overlapping region of MRI-GTV and SPECT-GTV, and the (SPECT/MRI)-GTV identified by the extension of SPECT-GTV outside MRI-GTV. 99m Results: MRI contrast-enhanced and Tc-MIBI SPECT-positive lesions were found in all 21 patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Strahlentherapie und Onkologie Springer Journals

Delineation of Target Volume for Radiotherapy of High-Grade Gliomas by 99mTc-MIBI SPECT and MRI Fusion

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References (34)

Publisher
Springer Journals
Copyright
Copyright © 2007 by Urban & Vogel München
Subject
Medicine & Public Health; Radiotherapy; Oncology
ISSN
0179-7158
eISSN
1439-099X
DOI
10.1007/s00066-007-1750-x
pmid
18040614
Publisher site
See Article on Publisher Site

Abstract

Strahlentherapie und Onkologie Original Article Delineation of Target Volume for Radiotherapy of High- 99m Grade Gliomas by Tc-MIBI SPECT and MRI Fusion 1 2 3 1 1 Marco Krengli , Gianfranco Loi , Gianmauro Sacchetti , Irene Manfredda , Giuseppina Gambaro , 2 4 3 Marco Brambilla , Alessandro Carriero , Eugenio Inglese Background and Purpose: Computed tomography (CT) and magnetic resonance imaging (MRI) are traditionally used for treat- 99m ment planning of high-grade glioma. Tc-methoxy-isobutyl-isonitrile (MIBI) single-photon emission computed tomography (SPECT) showed high sensitivity and specificity in literature series. In the present study, it was investigated how the information 99m provided by Tc-MIBI SPECT and MRI fusion could affect target delineation for radiotherapy of high-grade glioma. 99m Patients and Methods: 21 patients with high-grade glioma were studied by MRI and Tc-MIBI SPECT imaging. The gross tumor volume (GTV) was outlined on MRI (MRI-GTV) and SPECT images (SPECT-GTV). Three additional volumes were analyzed: the (MRI+SPECT)-GTV representing the whole amount of MRI-GTV plus SPECT-GTV, the (MRI&SPECT)-GTV identified by the overlapping region of MRI-GTV and SPECT-GTV, and the (SPECT/MRI)-GTV identified by the extension of SPECT-GTV outside MRI-GTV. 99m Results: MRI contrast-enhanced and Tc-MIBI SPECT-positive lesions were found in all 21 patients.

Journal

Strahlentherapie und OnkologieSpringer Journals

Published: Jan 1, 2007

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