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Dendritic versus somatic resonance

Dendritic versus somatic resonance Zhuchkova and Schreiber BMC Neuroscience 2011, 12(Suppl 1):P289 http://www.biomedcentral.com/1471-2202/12/S1/P289 POSTER PRESENTATION Open Access 1,2* 1,2 Ekaterina A Zhuchkova , Susanne Schreiber From Twentieth Annual Computational Neuroscience Meeting: CNS*2011 Stockholm, Sweden. 23-28 July 2011 Membrane-potential resonance characterizes the ability active conductances within the cell. In addition, we of a neuron to selectively respond to stimuli in a pre- show that although dendritic resonance may not show ferred frequency band. It has been associated with the up somatically, indirect consequences of dendritic reso- occurrence of subthreshold membrane-potential oscilla- nance can affect the soma. In particular, MPOs of den- tions (MPOs) and has been shown to be of functional dritic resonance-induced origin may propagate to the relevance, as exemplified by the correlation of resonance soma, leading to a situation where such cells when mea- frequencies with the spacing of grid fields in the entorh- sured somatically do exhibit subthreshold MPOs in the inal cortex [1] and the dependence of this spacing on the apparent “absence” of resonance. resonating H current [2]. A local dendritic resonance filters dendritic inputs - Resonance arises from the interaction of passive and even if it should not show up somatically - and is hence active membrane properties, usually requiring the pre- crucial for the flow of information in neuronal networks. sence of slowly-activating conductances that act as high- It is therefore important to identify the circumstances pass filters and are able to effectively oppose slow under which dendritic resonance could be missed in changes of the membrane potential. The distribution of somatic assessment of resonance properties. slow conductances responsible for resonance (like H or M), however, can differ between the compartments Acknowledgments within a neuron. In CA1 neurons, for example, it is This work was supported by the DFG (SFB 618) and the BMBF (BCCN Berlin, known that the density of H channels increases by more BPCN). than 60-fold from soma to dendrites and is largest in the Author details distal parts of the dendritic tree [3]. Accordingly, reso- 1 Institute for Theoretical Biology, Humboldt University, Berlin, 10115, nance can also depend on the spatial localization within a Germany. Bernstein Center for Computational Neuroscience, Berlin, 10115, Germany. cell. Still, cells are usually classified as either resonant or nonresonant on the basis of somatic injection of ZAP Published: 18 July 2011 currents (sine-wave functions with a linear increase in frequency). References 1. Giocomo LM, Zilli EA, Francen E, Hasselmo ME: Temporal frequency of Here, we investigate to what extent and under which subthreshold oscillations scales with entorhinal grid cell field spacing. circumstances cells with dendritic resonance may be Science 2007, 315:1719-1722. misclassified as nonresonant by somatic measurement of 2. Giocomo LM, Hasselmo ME: Knock-out of HCN1 subunit flattens dorsal- ventral frequency gradient of medial entorhinal neurons in adult mice. J resonance properties. We use simple conductance-based Neurosci 2009, 29:7625-7630. multicompartmental models to analyze the effect of 3. Lorincz A, Notomi T, Tamas G, Shigemoto R, Nusser Z: Polarized and dendritic resonance on somatic input (and hence reso- compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nat Neurosci 2002, 5:1185-1193. nance estimates based on somatic recordings). We find that indeed, even a strong dendritic resonance may not doi:10.1186/1471-2202-12-S1-P289 Cite this article as: Zhuchkova and Schreiber: Dendritic versus somatic be detectable with somatic ZAP protocols. The extent resonance. BMC Neuroscience 2011 12(Suppl 1):P289. to which dendritic resonance is masked depends on neuronal morphology as well as the distribution of Institute for Theoretical Biology, Humboldt University, Berlin, 10115, Germany Full list of author information is available at the end of the article © 2011 Zhuchkova and Schreiber; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BMC Neuroscience Springer Journals

Dendritic versus somatic resonance

Zhuchkova, Ekaterina; Schreiber, Susanne
BMC Neuroscience , Volume 12 (1) – Jul 18, 2011
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Springer Journals
Copyright
Copyright © 2011 by Zhuchkova and Schreiber; licensee BioMed Central Ltd.
Subject
Biomedicine; Neurosciences; Neurobiology; Animal Models
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1471-2202
DOI
10.1186/1471-2202-12-S1-P289
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Abstract

Zhuchkova and Schreiber BMC Neuroscience 2011, 12(Suppl 1):P289 http://www.biomedcentral.com/1471-2202/12/S1/P289 POSTER PRESENTATION Open Access 1,2* 1,2 Ekaterina A Zhuchkova , Susanne Schreiber From Twentieth Annual Computational Neuroscience Meeting: CNS*2011 Stockholm, Sweden. 23-28 July 2011 Membrane-potential resonance characterizes the ability active conductances within the cell. In addition, we of a neuron to selectively respond to stimuli in a pre- show that although dendritic resonance may not show ferred frequency band. It has been associated with the up somatically, indirect consequences of dendritic reso- occurrence of subthreshold membrane-potential oscilla- nance can affect the soma. In particular, MPOs of den- tions (MPOs) and has been shown to be of functional dritic resonance-induced origin may propagate to the relevance, as exemplified by the correlation of resonance soma, leading to a situation where such cells when mea- frequencies with the spacing of grid fields in the entorh- sured somatically do exhibit subthreshold MPOs in the inal cortex [1] and the dependence of this spacing on the apparent “absence” of resonance. resonating H current [2]. A local dendritic resonance filters dendritic inputs - Resonance arises from the interaction of passive and even if it should not show up somatically - and is hence active membrane properties, usually requiring the pre- crucial for the flow of information in neuronal networks. sence of slowly-activating conductances that act as high- It is therefore important to identify the circumstances pass filters and are able to effectively oppose slow under which dendritic resonance could be missed in changes of the membrane potential. The distribution of somatic assessment of resonance properties. slow conductances responsible for resonance (like H or M), however, can differ between the compartments Acknowledgments within a neuron. In CA1 neurons, for example, it is This work was supported by the DFG (SFB 618) and the BMBF (BCCN Berlin, known that the density of H channels increases by more BPCN). than 60-fold from soma to dendrites and is largest in the Author details distal parts of the dendritic tree [3]. Accordingly, reso- 1 Institute for Theoretical Biology, Humboldt University, Berlin, 10115, nance can also depend on the spatial localization within a Germany. Bernstein Center for Computational Neuroscience, Berlin, 10115, Germany. cell. Still, cells are usually classified as either resonant or nonresonant on the basis of somatic injection of ZAP Published: 18 July 2011 currents (sine-wave functions with a linear increase in frequency). References 1. Giocomo LM, Zilli EA, Francen E, Hasselmo ME: Temporal frequency of Here, we investigate to what extent and under which subthreshold oscillations scales with entorhinal grid cell field spacing. circumstances cells with dendritic resonance may be Science 2007, 315:1719-1722. misclassified as nonresonant by somatic measurement of 2. Giocomo LM, Hasselmo ME: Knock-out of HCN1 subunit flattens dorsal- ventral frequency gradient of medial entorhinal neurons in adult mice. J resonance properties. We use simple conductance-based Neurosci 2009, 29:7625-7630. multicompartmental models to analyze the effect of 3. Lorincz A, Notomi T, Tamas G, Shigemoto R, Nusser Z: Polarized and dendritic resonance on somatic input (and hence reso- compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nat Neurosci 2002, 5:1185-1193. nance estimates based on somatic recordings). We find that indeed, even a strong dendritic resonance may not doi:10.1186/1471-2202-12-S1-P289 Cite this article as: Zhuchkova and Schreiber: Dendritic versus somatic be detectable with somatic ZAP protocols. The extent resonance. BMC Neuroscience 2011 12(Suppl 1):P289. to which dendritic resonance is masked depends on neuronal morphology as well as the distribution of Institute for Theoretical Biology, Humboldt University, Berlin, 10115, Germany Full list of author information is available at the end of the article © 2011 Zhuchkova and Schreiber; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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BMC Neuroscience – Springer Journals

Published: Jul 18, 2011

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