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Deregulation of microRNA expression in peripheral blood mononuclear cells from patients with HCV-related malignancies

Deregulation of microRNA expression in peripheral blood mononuclear cells from patients with... Hepatol Int (2015) 9:586–593 DOI 10.1007/s12072-015-9658-5 ORIGINAL ARTICLE Deregulation of microRNA expression in peripheral blood mononuclear cells from patients with HCV-related malignancies 1 1 1 2 • • • • Alessia Piluso Laura Gragnani Elisa Fognani Elena Grandini 1 1 2 2 • • • • Monica Monti Cristina Stasi Elisabetta Loggi Marzia Margotti 2 2 1 • • Fabio Conti Pietro Andreone Anna Linda Zignego Received: 23 March 2015 / Accepted: 27 July 2015 / Published online: 14 August 2015 Asian Pacific Association for the Study of the Liver 2015 Abstract Results Our results showed an upregulation of miRNA- Background and aim Hepatocellular carcinoma is one of 21 and downregulation of miRNA-26b in hepatocellular the major causes of death due to cancer worldwide, and its carcinoma and non-Hodgkin’s lymphoma patients com- association with hepatitis C virus infection has been pared to controls (p\ 0.001). Deregulation of miRNA-16 definitively established. Hepatitis C virus is also involved and miRNA-155 was limited to lymphoma patients. in the pathogenesis of non-Hodgkin’s lymphoma. This is Conclusions This study shows that some microRNAs are the only virus infecting humans that is able to induce two differently expressed in peripheral blood mononuclear cells different malignancies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hepatology International Springer Journals

Deregulation of microRNA expression in peripheral blood mononuclear cells from patients with HCV-related malignancies

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References (44)

Publisher
Springer Journals
Copyright
Copyright © 2015 by Asian Pacific Association for the Study of the Liver
Subject
Medicine & Public Health; Hepatology; Colorectal Surgery; Surgery
ISSN
1936-0533
eISSN
1936-0541
DOI
10.1007/s12072-015-9658-5
pmid
26272105
Publisher site
See Article on Publisher Site

Abstract

Hepatol Int (2015) 9:586–593 DOI 10.1007/s12072-015-9658-5 ORIGINAL ARTICLE Deregulation of microRNA expression in peripheral blood mononuclear cells from patients with HCV-related malignancies 1 1 1 2 • • • • Alessia Piluso Laura Gragnani Elisa Fognani Elena Grandini 1 1 2 2 • • • • Monica Monti Cristina Stasi Elisabetta Loggi Marzia Margotti 2 2 1 • • Fabio Conti Pietro Andreone Anna Linda Zignego Received: 23 March 2015 / Accepted: 27 July 2015 / Published online: 14 August 2015 Asian Pacific Association for the Study of the Liver 2015 Abstract Results Our results showed an upregulation of miRNA- Background and aim Hepatocellular carcinoma is one of 21 and downregulation of miRNA-26b in hepatocellular the major causes of death due to cancer worldwide, and its carcinoma and non-Hodgkin’s lymphoma patients com- association with hepatitis C virus infection has been pared to controls (p\ 0.001). Deregulation of miRNA-16 definitively established. Hepatitis C virus is also involved and miRNA-155 was limited to lymphoma patients. in the pathogenesis of non-Hodgkin’s lymphoma. This is Conclusions This study shows that some microRNAs are the only virus infecting humans that is able to induce two differently expressed in peripheral blood mononuclear cells different malignancies.

Journal

Hepatology InternationalSpringer Journals

Published: Aug 14, 2015

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