Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Does EEG Predict Response to Valproate Versus Lithium in Patients with Mania?

Does EEG Predict Response to Valproate Versus Lithium in Patients with Mania? A number of factors may suggest that a patient with mania may respond to valproate or to lithium. However, prediction of which patients will respond to either medication remains difficult. In this study nonepileptiform EEG abnormalities in responders to each medication were investigated. Six of 20 patients (30%) responsive to lithium but not to valproate had nonepileptiform EEG abnormalities while 14 of 20 patients (70%) responsive to valproate but not to lithium had nonepileptiform EEG abnormalities. Patients presenting with mania and EEG abnormalities, particularly sharp activity, are statistically more likely (χ2 = 4.9, df = 1, p = .027) to respond to valproate than to lithium. Whether such a finding will also hold true for other anticonvulsants used to treat mania remains to be seen. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Clinical Psychiatry Springer Journals

Does EEG Predict Response to Valproate Versus Lithium in Patients with Mania?

Download PDF
5 pages

Loading next page...
 
/lp/springer-journals/does-eeg-predict-response-to-valproate-versus-lithium-in-patients-with-QIioKBij7O
Publisher
Springer Journals
Copyright
Copyright © 2001 by American Academy of Clinical Psychiatrists
Subject
Medicine & Public Health; Neurology; Psychiatry; Psychopharmacology
ISSN
1040-1237
eISSN
1573-3238
DOI
10.1023/A:1016611506740
Publisher site
See Article on Publisher Site

Abstract

A number of factors may suggest that a patient with mania may respond to valproate or to lithium. However, prediction of which patients will respond to either medication remains difficult. In this study nonepileptiform EEG abnormalities in responders to each medication were investigated. Six of 20 patients (30%) responsive to lithium but not to valproate had nonepileptiform EEG abnormalities while 14 of 20 patients (70%) responsive to valproate but not to lithium had nonepileptiform EEG abnormalities. Patients presenting with mania and EEG abnormalities, particularly sharp activity, are statistically more likely (χ2 = 4.9, df = 1, p = .027) to respond to valproate than to lithium. Whether such a finding will also hold true for other anticonvulsants used to treat mania remains to be seen.

Journal

Annals of Clinical Psychiatry – Springer Journals

Published: Oct 22, 2004

References

  • Current therapeutic profile of lithium
    Gershon, S; Soares, JC
  • The lithium ion: A foundation for psychopharmacological specificity
    Soares, JC; Gershon, S
  • Lithium therapy: Limitations and alternatives in the treatment of bipolar disorders
    Calabrese, JR; Woyshville, MJ
  • Schizoaffective mania reconsidered
    Levinson, DF; Levitt, MEM
  • Comprehensive review of the psychiatric uses of valproate
    Davis, LL; Ryan, W; Adinoff, B; Petty, F
  • Efficacy of divalproex vs lithium and placebo in the treatment of mania
    Bowden, CL; Brugger, AM; Swann, AC; Calabrese, JR; Janicak, PG; Petty, F; Dilsaver, SC; Davis, JM; Rush, AJ; Small, JG; Garza-Trevino, ES; Risch, SC; Goodnick, PJ; Morrig, D. F. t. D. M. S. G.
  • A double-blind comparison of valproate and lithium in the treatment of acute mania
    Freeman, TW; Clothier, JL; Pazzaglia, P; Legan, MD; Swann, AC
  • Valproate in the treatment of acute mania
    Pope, HG; McElroy, SL; Keck, PE; Hudson, JI
  • Correlates of antimanic response to valproate
    McElroy, SL; Keck, PE; Pope, HG; Hudson, JI; Morris, D.
  • The use of sodium valproate, carbamazepine and oxcarbazepine in patients with affective disorders
    Emrich, HM; Dose, M; Vonzerssen, D.
  • The manic syndrome: Factors which may predict a patient's response to lithium, carbamazepine and valproate
    Dilsaver, SC; Swann, AC; Shoaib, AM; Bowers, TC
  • Predictors of valproate response in in bipolar rapid cycling
    Calabrese, JR; Woyshville, MJ; Kimmel, SE; Rapport, DJ
  • NIMH workshop report on treatment of bipolar disorder
    Prien, RF; Potter, WZ
  • Differential effect of number of previous episodes of affective disorder on response to lithium or divalproex in acute mania
    Swann, AC; Bowden, CL; Calabrese, JR; Dilsaver, SC; Morris, DD
  • Sodium valproate: Its use in primary psychiatric disorders
    McElroy, SL; Keck, PE; Pope, HG
  • Treatment of psychiatric disorders with valproate: A series of 73 cases
    McElroy, SL; Pope, HG; Keck, PE; Hudson, JI
  • Correlates of antimanic response to valproate
    McElroy, SL; Keck, PE; Pope, HG; Hudson, JI; Morris, D
  • Diagnostic and Statistical Manual of Mental Disorders
  • Handbook of Psychiatric Diagnostic Procedures
    Struve, FA
  • Lithium-specific pathological electroencephalographic changes: A successful replication of earlier investigative results
    Struve, FA
  • A glossary of terms most commonly used by clinical electroencephalographers
    Chatrian, GE; Bergamini, L; Dondey, M; Klass, DW; Lennox-Buchkhal, M; Petersen, I
  • Spehlmann's EEG Primer
    Fisch, BJ
  • Current Practice of Clinical Electroencephalography
    Zifkin, BG; Cracco, RQ