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Editorial: Special issue on purinergic signalling and calcification

Editorial: Special issue on purinergic signalling and calcification Purinergic Signalling https://doi.org/10.1007/s11302-023-09949-8 EDITORIAL 1 2 Isabel R. Orriss  · Timothy R. Arnett © The Author(s), under exclusive licence to Springer Nature B.V. 2023 Over the last 2 decades, a new role for ATP as an extracel- TNAP and NPP1 are present at equal levels, these enzymes lular regulatory molecule has emerged. Many independent function synergistically to produce a P /PP ratio conducive i i studies have now shown that extracellular ATP additionally to mineralisation. functions as an important inhibitor of tissue calcification, Alterations in the P /PP ratio can have a significant i i particularly in the skeletal and cardiovascular systems. This negative impact on the mineralisation of the skeleton, for novel action of ATP may occur not only via “classical” P2 example, in hypophosphatasia, a genetic disease caused by receptor-mediated pathways but also because extracellular mutations in the TNAP gene. In contrast, in blood vessels, ATP is hydrolysed by ecto-nucleotide pyrophosphatase/increased P relative to PP can lead to pathological calcifica- i i phosphodiesterase 1 (NPP1), to yield pyrophosphate (PP ), tion. The review by Villa-Belosta provides an overview of a critical physiochemical inhibitor of mineralisation that the important role that purinergic signalling and extracellu- acts as the body’s ubiquitous “natural water http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Purinergic Signalling Springer Journals

Editorial: Special issue on purinergic signalling and calcification

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Editorial: Special issue on purinergic signalling and calcification

Abstract

Purinergic Signalling https://doi.org/10.1007/s11302-023-09949-8 EDITORIAL 1 2 Isabel R. Orriss  · Timothy R. Arnett © The Author(s), under exclusive licence to Springer Nature B.V. 2023 Over the last 2 decades, a new role for ATP as an extracel- TNAP and NPP1 are present at equal levels, these enzymes lular regulatory molecule has emerged. Many independent function synergistically to produce a P /PP ratio conducive i i studies have now shown that...
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Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to Springer Nature B.V. 2023
ISSN
1573-9538
eISSN
1573-9546
DOI
10.1007/s11302-023-09949-8
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Abstract

Purinergic Signalling https://doi.org/10.1007/s11302-023-09949-8 EDITORIAL 1 2 Isabel R. Orriss  · Timothy R. Arnett © The Author(s), under exclusive licence to Springer Nature B.V. 2023 Over the last 2 decades, a new role for ATP as an extracel- TNAP and NPP1 are present at equal levels, these enzymes lular regulatory molecule has emerged. Many independent function synergistically to produce a P /PP ratio conducive i i studies have now shown that extracellular ATP additionally to mineralisation. functions as an important inhibitor of tissue calcification, Alterations in the P /PP ratio can have a significant i i particularly in the skeletal and cardiovascular systems. This negative impact on the mineralisation of the skeleton, for novel action of ATP may occur not only via “classical” P2 example, in hypophosphatasia, a genetic disease caused by receptor-mediated pathways but also because extracellular mutations in the TNAP gene. In contrast, in blood vessels, ATP is hydrolysed by ecto-nucleotide pyrophosphatase/increased P relative to PP can lead to pathological calcifica- i i phosphodiesterase 1 (NPP1), to yield pyrophosphate (PP ), tion. The review by Villa-Belosta provides an overview of a critical physiochemical inhibitor of mineralisation that the important role that purinergic signalling and extracellu- acts as the body’s ubiquitous “natural water

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Purinergic Signalling – Springer Journals

Published: Jun 1, 2023

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