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Emerging structures and ligands for P2X3 and P2X4 receptors—towards novel treatments of neuropathic pain

Emerging structures and ligands for P2X3 and P2X4 receptors—towards novel treatments of... Purinergic Signalling (2010) 6:145–148 DOI 10.1007/s11302-010-9182-y HIGHLIGHTS IN PURINERGIC SIGNALLING Emerging structures and ligands for P2X and P2X 3 4 receptors—towards novel treatments of neuropathic pain Christa E. Müller Published online: 16 May 2010 Springer Science+Business Media B.V. 2010 Kawate T, Michel JC, Birdsong WT, Gouaux E (2009) heterogeneity. Expression in Sf9 insect cells using a Crystal structure of the ATP-gated P2X ion channel baculovirus expression system yielded large amounts for in the closed state. Nature 460:592–598 crystallization, which was performed after solubilization of the membranes with n-dodecyl-β-D-maltoside followed by Article summary metal–ion affinity and size exclusion chromatography. The X-ray structure confirmed that the receptor was formed of The paper by Kawate et al. describes the X-ray structure of three subunits and contained six transmembrane α-helices, the zebrafish P2X receptor in the closed state at 3.1 Å two of each subunit. The large extracellular domain resolution. This presents the very first crystal structure of a protruded ca. 70 Å above the membrane. Subunit–subunit P2X receptor subtype. It was obtained by the following interactions were mainly mediated by the extracellular strategy: 35 different P2X receptor orthologues were domains. The X-ray structure, although in the closed state transiently transfected into HEK293 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Purinergic Signalling Springer Journals

Emerging structures and ligands for P2X3 and P2X4 receptors—towards novel treatments of neuropathic pain

Müller, Christa
Purinergic Signalling , Volume 6 (2) – May 16, 2010
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Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer Science+Business Media B.V.
Subject
Biomedicine; Cancer Research ; Neurosciences ; Human Physiology ; Pharmacology/Toxicology ; Biomedicine general
ISSN
1573-9538
eISSN
1573-9546
DOI
10.1007/s11302-010-9182-y
pmid
20806006
Publisher site
See Article on Publisher Site

Abstract

Purinergic Signalling (2010) 6:145–148 DOI 10.1007/s11302-010-9182-y HIGHLIGHTS IN PURINERGIC SIGNALLING Emerging structures and ligands for P2X and P2X 3 4 receptors—towards novel treatments of neuropathic pain Christa E. Müller Published online: 16 May 2010 Springer Science+Business Media B.V. 2010 Kawate T, Michel JC, Birdsong WT, Gouaux E (2009) heterogeneity. Expression in Sf9 insect cells using a Crystal structure of the ATP-gated P2X ion channel baculovirus expression system yielded large amounts for in the closed state. Nature 460:592–598 crystallization, which was performed after solubilization of the membranes with n-dodecyl-β-D-maltoside followed by Article summary metal–ion affinity and size exclusion chromatography. The X-ray structure confirmed that the receptor was formed of The paper by Kawate et al. describes the X-ray structure of three subunits and contained six transmembrane α-helices, the zebrafish P2X receptor in the closed state at 3.1 Å two of each subunit. The large extracellular domain resolution. This presents the very first crystal structure of a protruded ca. 70 Å above the membrane. Subunit–subunit P2X receptor subtype. It was obtained by the following interactions were mainly mediated by the extracellular strategy: 35 different P2X receptor orthologues were domains. The X-ray structure, although in the closed state transiently transfected into HEK293

Journal

Purinergic Signalling – Springer Journals

Published: May 16, 2010

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