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Enkephalin binding systems in human plasma III: Comparative protection of different peptides

Enkephalin binding systems in human plasma III: Comparative protection of different peptides We have investigated the hydrolysis and protection from hydrolysis of several peptides by plasma enzymes and by the plasma components previously described as inhibitors of enkephalins' hydrolysis. The results shown indicate that all the peptides actually hydrolyzed are also partially protected from hydrolysis by the enkephalin-protecting substances. Protection is fairly uniform for all the peptides tested, but considerably higher in the case of leu- and met-enkephalin, suggesting a partial specificity of the protecting substances towards opioid peptides. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurochemical Research Springer Journals

Enkephalin binding systems in human plasma III: Comparative protection of different peptides

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References (19)

Publisher
Springer Journals
Copyright
Copyright
Subject
Biomedicine; Neurosciences; Neurochemistry; Biochemistry, general; Cell Biology; Neurology
ISSN
0364-3190
eISSN
1573-6903
DOI
10.1007/BF00971536
Publisher site
See Article on Publisher Site

Abstract

We have investigated the hydrolysis and protection from hydrolysis of several peptides by plasma enzymes and by the plasma components previously described as inhibitors of enkephalins' hydrolysis. The results shown indicate that all the peptides actually hydrolyzed are also partially protected from hydrolysis by the enkephalin-protecting substances. Protection is fairly uniform for all the peptides tested, but considerably higher in the case of leu- and met-enkephalin, suggesting a partial specificity of the protecting substances towards opioid peptides.

Journal

Neurochemical ResearchSpringer Journals

Published: Dec 28, 2004

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