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Eosinophils as mediators of antibody-dependent damage to schistosomula

Eosinophils as mediators of antibody-dependent damage to schistosomula WE have reported previously1 that damage to schistosomula can be assayed by measuring release of 51Cr from labelled larvae. Using this technique, we have shown that schistosomula can be damaged by a combination of normal human peripheral blood leukocytes and of heat-inactivated sera from patients infected with Schistosoma mansoni1. We now present evidence that the eosinophil is substantially the most active mediator of damage in normal peripheral blood, but that cells from eosinophilic patients are relatively inactive. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Eosinophils as mediators of antibody-dependent damage to schistosomula

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References (11)

Publisher
Springer Journals
Copyright
Copyright © 1975 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/256727a0
Publisher site
See Article on Publisher Site

Abstract

WE have reported previously1 that damage to schistosomula can be assayed by measuring release of 51Cr from labelled larvae. Using this technique, we have shown that schistosomula can be damaged by a combination of normal human peripheral blood leukocytes and of heat-inactivated sera from patients infected with Schistosoma mansoni1. We now present evidence that the eosinophil is substantially the most active mediator of damage in normal peripheral blood, but that cells from eosinophilic patients are relatively inactive.

Journal

NatureSpringer Journals

Published: Aug 28, 1975

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