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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse Childhood abuse or neglect alters the hormonal stress response and increases the risk for suicide. Analysis of hippocampal samples from human suicide victims with a history of child abuse indicated changes in the expression of the NC3R1 gene that did not occur in suicide victims with no childhood abuse or in people who died of other causes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Neuroscience Springer Journals

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

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References (59)

Publisher
Springer Journals
Copyright
Copyright © 2009 by Nature Publishing Group
Subject
Biomedicine; Biomedicine, general; Neurosciences; Behavioral Sciences; Biological Techniques; Neurobiology; Animal Genetics and Genomics
ISSN
1097-6256
eISSN
1546-1726
DOI
10.1038/nn.2270
Publisher site
See Article on Publisher Site

Abstract

Childhood abuse or neglect alters the hormonal stress response and increases the risk for suicide. Analysis of hippocampal samples from human suicide victims with a history of child abuse indicated changes in the expression of the NC3R1 gene that did not occur in suicide victims with no childhood abuse or in people who died of other causes.

Journal

Nature NeuroscienceSpringer Journals

Published: Feb 22, 2009

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