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Epistatic effect of genes from the dopamine and serotonin systems on the temperament traits of Novelty Seeking and Harm Avoidance

Epistatic effect of genes from the dopamine and serotonin systems on the temperament traits of... Scientific Correspondence genotype distributions of this SNP do not deviate from study in other population and subgroups of schizo- Hardy–Weinberg equilibrium in both patients and con- phrenia. trols. The genotype and allele frequencies of this SNP 1 2 3 3 in both patients and controls were listed in Table 1. M-L Chen , S-Y Chen , C-H Huang and C-H Chen No significant differences of genotype or allele fre- Institute of Medical Sciences, Tzu-Chi University, quency were detected between patients and controls, Hualien City, Taiwan; Department of Life Sciences, suggesting that this SNP is unlikely involved in the Tzu-Chi University, Hualien City, Taiwan; Depart- pathogenesis of schizophrenia. ment of Psychiatry, Tzu-Chi General Hospital, Hualien Reeler mouse is an autosomal recessive mutant City, Taiwan mouse with defective reelin gene. Heterozygous reeler Correspondence should be addressed to: C-H Chen. E-mail: cchen mouse showed 50% decrease of reelin mRNA and pro- mail.tcu.edu.tw tein in the brain, deficits in prepulse inhibition of startle, indicating a possible link of genetic defects of reelin gene and pathogenesis of schizophrenia. In humans, mutations in the reelin gene were found to be 1 Impagnatiello F et al. Proc Natl Acad Sci USA 1998; 95: 15718– associated with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Psychiatry Springer Journals

Epistatic effect of genes from the dopamine and serotonin systems on the temperament traits of Novelty Seeking and Harm Avoidance

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References (13)

Publisher
Springer Journals
Copyright
Copyright © 2002 by Macmillan Publishers Limited
Subject
Medicine & Public Health; Medicine/Public Health, general; Psychiatry; Neurosciences; Behavioral Sciences; Pharmacotherapy; Biological Psychology
ISSN
1359-4184
eISSN
1476-5578
DOI
10.1038/sj.mp.4001005
Publisher site
See Article on Publisher Site

Abstract

Scientific Correspondence genotype distributions of this SNP do not deviate from study in other population and subgroups of schizo- Hardy–Weinberg equilibrium in both patients and con- phrenia. trols. The genotype and allele frequencies of this SNP 1 2 3 3 in both patients and controls were listed in Table 1. M-L Chen , S-Y Chen , C-H Huang and C-H Chen No significant differences of genotype or allele fre- Institute of Medical Sciences, Tzu-Chi University, quency were detected between patients and controls, Hualien City, Taiwan; Department of Life Sciences, suggesting that this SNP is unlikely involved in the Tzu-Chi University, Hualien City, Taiwan; Depart- pathogenesis of schizophrenia. ment of Psychiatry, Tzu-Chi General Hospital, Hualien Reeler mouse is an autosomal recessive mutant City, Taiwan mouse with defective reelin gene. Heterozygous reeler Correspondence should be addressed to: C-H Chen. E-mail: cchen mouse showed 50% decrease of reelin mRNA and pro- mail.tcu.edu.tw tein in the brain, deficits in prepulse inhibition of startle, indicating a possible link of genetic defects of reelin gene and pathogenesis of schizophrenia. In humans, mutations in the reelin gene were found to be 1 Impagnatiello F et al. Proc Natl Acad Sci USA 1998; 95: 15718– associated with

Journal

Molecular PsychiatrySpringer Journals

Published: Jun 18, 2002

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