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Extramedullary haematopoiesis presenting with paraparesis

Extramedullary haematopoiesis presenting with paraparesis Acta Neurol Belg (2014) 114:311–312 DOI 10.1007/s13760-013-0254-y N E URO- IMA G ES • • • Rahat Brar Abhishek Prasad Shaleen Rana Vaibhav Pratap Singh Received: 25 September 2013 / Accepted: 27 September 2013 / Published online: 9 October 2013 Belgian Neurological Society 2013 A 27-year-old male presented with 6-month history of weakness of the bilateral lower limbs with progressive difficulty in walking which ultimately led to paraplegia. He also had sphincter disturbances and was diagnosed with thalassemia at the age of 10 years. MRI of the spine, which was performed for his present complaints revealed epidural soft tissue density masses extending from the T4 to the T9 vertebral bodies causing severe cord compression (Fig. 1). In addition, there were large paravertebral masses and the posterior ends of the ribs appeared expanded (Fig. 2). The normal vertebral bone marrow fat was replaced by homogenous low signal infiltrates, signifying a diffuse marrow infiltrative disease. This appearance of the paravertebral masses along with the known underlying thalassemia was suggestive of extra- medullary haematopoiesis (EMH). Spinal cord compression due to EMH is a rare compli- cation of haematological conditions like thalassemia [1]. The treatment options include radiotherapy of the highly radio-sensitive marrow http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Neurologica Belgica Springer Journals

Extramedullary haematopoiesis presenting with paraparesis

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Publisher
Springer Journals
Copyright
Copyright © 2013 by Belgian Neurological Society
Subject
Biomedicine; Neurosciences; Neurology; Neuroradiology; Medicine/Public Health, general
ISSN
0300-9009
eISSN
2240-2993
DOI
10.1007/s13760-013-0254-y
pmid
24104868
Publisher site
See Article on Publisher Site

Abstract

Acta Neurol Belg (2014) 114:311–312 DOI 10.1007/s13760-013-0254-y N E URO- IMA G ES • • • Rahat Brar Abhishek Prasad Shaleen Rana Vaibhav Pratap Singh Received: 25 September 2013 / Accepted: 27 September 2013 / Published online: 9 October 2013 Belgian Neurological Society 2013 A 27-year-old male presented with 6-month history of weakness of the bilateral lower limbs with progressive difficulty in walking which ultimately led to paraplegia. He also had sphincter disturbances and was diagnosed with thalassemia at the age of 10 years. MRI of the spine, which was performed for his present complaints revealed epidural soft tissue density masses extending from the T4 to the T9 vertebral bodies causing severe cord compression (Fig. 1). In addition, there were large paravertebral masses and the posterior ends of the ribs appeared expanded (Fig. 2). The normal vertebral bone marrow fat was replaced by homogenous low signal infiltrates, signifying a diffuse marrow infiltrative disease. This appearance of the paravertebral masses along with the known underlying thalassemia was suggestive of extra- medullary haematopoiesis (EMH). Spinal cord compression due to EMH is a rare compli- cation of haematological conditions like thalassemia [1]. The treatment options include radiotherapy of the highly radio-sensitive marrow

Journal

Acta Neurologica Belgica – Springer Journals

Published: Oct 9, 2013

References

  • Extramedullary haemopoiesis in thalassemia intermedia presenting as paraplegia
    Tan, TC; Tsao, J; Cheung, FC
  • Paraplegia due to spinal cord compression by extramedullary erythropoietic tissue in a thalassaemia intermedia patient with gynecomastia secondary to cirrhosis: successful treatment with hydroxyurea
    Gamberini, MR; Fortini, M; Sanctis, V