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Fipronil-Induced Biochemical Alterations During Oral Subacute Toxicity in Buffalo Calves

Fipronil-Induced Biochemical Alterations During Oral Subacute Toxicity in Buffalo Calves In the present investigation, detailed oral subacute toxicity study of fipronil, a phenylpyrazole insecticide, was undertaken in male buffalo calves. In oral subacute toxicity study, fipronil was administrated to male buffalo calves at repeated oral dose of 0.5 mg kg−1 day−1 for 21 consecutive days. Fipronil produced varying degree of mild to moderate toxic signs in buffalo calves. Fipronil produced toxic signs of salivation, lachrymal discharge, dullness, depression, decreased body weight gain, alopecia and sunken eyes. All the fipronil-exposed animals recovered within 7 days after insecticidal treatment was stopped. Repeated oral administration of fipronil at the dose rate of 0.5 mg kg−1 day−1 for 21 consecutive days produced significant elevation of whole blood cholinesterase to the extent of 45.17 %. Fipronil on repeated oral administration produced significant increase in the plasma levels of lactate dehydrogenase (7.08 %), aspartate aminotransferase (43.55 %) and acid phosphatase (11.647), but no significant effect on the plasma levels of alanine aminotransferase and alkaline phosphatase in male buffalo calves. Subacute oral administration of fipronil elevated the levels of gamma-glutamyl transferase (25.53 %), total plasma proteins (20.59 %) and blood glucose (40.75 %). However, no significant alteration in the levels of blood urea nitrogen, plasma creatinine and cholesterol was seen following daily oral administration of fipronil in the buffalo calves. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Proceedings of the National Academy of Sciences, India Section B: Biological Sciences Springer Journals

Fipronil-Induced Biochemical Alterations During Oral Subacute Toxicity in Buffalo Calves

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References (22)

Publisher
Springer Journals
Copyright
Copyright © 2013 by The National Academy of Sciences, India
Subject
Life Sciences; Life Sciences, general; Behavioural Sciences; Plant Biochemistry; Nucleic Acid Chemistry
ISSN
0369-8211
eISSN
2250-1746
DOI
10.1007/s40011-013-0167-9
Publisher site
See Article on Publisher Site

Abstract

In the present investigation, detailed oral subacute toxicity study of fipronil, a phenylpyrazole insecticide, was undertaken in male buffalo calves. In oral subacute toxicity study, fipronil was administrated to male buffalo calves at repeated oral dose of 0.5 mg kg−1 day−1 for 21 consecutive days. Fipronil produced varying degree of mild to moderate toxic signs in buffalo calves. Fipronil produced toxic signs of salivation, lachrymal discharge, dullness, depression, decreased body weight gain, alopecia and sunken eyes. All the fipronil-exposed animals recovered within 7 days after insecticidal treatment was stopped. Repeated oral administration of fipronil at the dose rate of 0.5 mg kg−1 day−1 for 21 consecutive days produced significant elevation of whole blood cholinesterase to the extent of 45.17 %. Fipronil on repeated oral administration produced significant increase in the plasma levels of lactate dehydrogenase (7.08 %), aspartate aminotransferase (43.55 %) and acid phosphatase (11.647), but no significant effect on the plasma levels of alanine aminotransferase and alkaline phosphatase in male buffalo calves. Subacute oral administration of fipronil elevated the levels of gamma-glutamyl transferase (25.53 %), total plasma proteins (20.59 %) and blood glucose (40.75 %). However, no significant alteration in the levels of blood urea nitrogen, plasma creatinine and cholesterol was seen following daily oral administration of fipronil in the buffalo calves.

Journal

Proceedings of the National Academy of Sciences, India Section B: Biological Sciences – Springer Journals

Published: Mar 12, 2013

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