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Fundamentals of Clinical ResearchDefining the Treatment Effect

Fundamentals of Clinical Research: Defining the Treatment Effect [In this book we will use the term “signal” to define the summary variable which, at a group level and in comparative terms, is used to formulate the hypothesis to be tested, in order to evaluate the effect of the experimental treatment under study. It should be noted that in clinical research the term signal is often used with a different meaning, to indicate an increased frequency of a given adverse event in the experimental treatment group over the control group, to the extent that the adverse event is suspected to be causally related to the experimental treatment. In this book we will use this term in the literal sense of “a sign to convey a command, direction, or warning” (Webster’s New World Dictionary, [103]).] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Fundamentals of Clinical ResearchDefining the Treatment Effect

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Publisher
Springer Milan
Copyright
© Springer-Verlag Italia, Milano 2007
ISBN
978-88-470-0491-7
Pages
58 –89
DOI
10.1007/978-88-470-0492-4_4
Publisher site
See Chapter on Publisher Site

Abstract

[In this book we will use the term “signal” to define the summary variable which, at a group level and in comparative terms, is used to formulate the hypothesis to be tested, in order to evaluate the effect of the experimental treatment under study. It should be noted that in clinical research the term signal is often used with a different meaning, to indicate an increased frequency of a given adverse event in the experimental treatment group over the control group, to the extent that the adverse event is suspected to be causally related to the experimental treatment. In this book we will use this term in the literal sense of “a sign to convey a command, direction, or warning” (Webster’s New World Dictionary, [103]).]

Published: Jan 1, 2007

Keywords: Experimental Treatment; Therapeutic Level; Peak Expiratory Flow Rate; Group Indicator; Severe Attack

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