Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Fundamentals of Clinical ResearchExperimental Design: the Randomized Blinded Study as an Instrument to Reduce Bias

Fundamentals of Clinical Research: Experimental Design: the Randomized Blinded Study as an... [From the previous chapter it should be clear that in most cases the before-after comparison in a single group of patients is an inadequate experimental design, as it fails to achieve comparisons free from bias. “Before” is not a good control for “after”, since the effects of many factors are mixed with the effect of the treatment, introducing all kinds of systematic errors. Generally, in this type of experimental design, bias has the effect of simulating or exaggerating the effect of the treatment.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Fundamentals of Clinical ResearchExperimental Design: the Randomized Blinded Study as an Instrument to Reduce Bias

Download PDF
27 pages

Loading next page...
 
/lp/springer-journals/fundamentals-of-clinical-research-experimental-design-the-randomized-iR9zF1gNBq
Publisher
Springer Milan
Copyright
© Springer-Verlag Italia, Milano 2007
ISBN
978-88-470-0491-7
Pages
200 –227
DOI
10.1007/978-88-470-0492-4_9
Publisher site
See Chapter on Publisher Site

Abstract

[From the previous chapter it should be clear that in most cases the before-after comparison in a single group of patients is an inadequate experimental design, as it fails to achieve comparisons free from bias. “Before” is not a good control for “after”, since the effects of many factors are mixed with the effect of the treatment, introducing all kinds of systematic errors. Generally, in this type of experimental design, bias has the effect of simulating or exaggerating the effect of the treatment.]

Published: Jan 1, 2007

Keywords: Randomization List; Assessment Bias; Allocation Ratio; Simple Randomization; Stratify Randomization

There are no references for this article.