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Gabapentin as an Adjunct to Standard Mood Stabilizers in Outpatients with Mixed Bipolar Symptomatology

Gabapentin as an Adjunct to Standard Mood Stabilizers in Outpatients with Mixed Bipolar... Gabapentin is a new adjunctive medication to antiseizure therapies. Anecdotal evidence suggests that it may also help to alleviate mood symptoms in patients with bipolar illness. An open-label study examined the effects of adjunctive gabapentin in bipolar patients with mixed symptoms who had previously demonstrated only partial treatment responses. Mood ratings and side-effect profiles were followed weekly in 10 patients for 1 month. Decreases in Hamilton depression (P < 0.05) and Bech mania ratings (P < 0.01) were evident in the first week of treatment and were sustained. Potent early improvements were noted in early, middle, and late insomnia. The results suggest that gabapentin may be of benefit to bipolar patients who only partially respond to other mood stabilizers. A favorable side-effect profile and rapid action make this drug an attractive choice as an adjunctive therapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Clinical Psychiatry Springer Journals

Gabapentin as an Adjunct to Standard Mood Stabilizers in Outpatients with Mixed Bipolar Symptomatology

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Publisher
Springer Journals
Copyright
Copyright © 1999 by American Academy of Clinical Psychiatrists
Subject
Medicine & Public Health; Neurology; Psychiatry; Psychopharmacology
ISSN
1040-1237
eISSN
1573-3238
DOI
10.1023/A:1022361412956
Publisher site
See Article on Publisher Site

Abstract

Gabapentin is a new adjunctive medication to antiseizure therapies. Anecdotal evidence suggests that it may also help to alleviate mood symptoms in patients with bipolar illness. An open-label study examined the effects of adjunctive gabapentin in bipolar patients with mixed symptoms who had previously demonstrated only partial treatment responses. Mood ratings and side-effect profiles were followed weekly in 10 patients for 1 month. Decreases in Hamilton depression (P < 0.05) and Bech mania ratings (P < 0.01) were evident in the first week of treatment and were sustained. Potent early improvements were noted in early, middle, and late insomnia. The results suggest that gabapentin may be of benefit to bipolar patients who only partially respond to other mood stabilizers. A favorable side-effect profile and rapid action make this drug an attractive choice as an adjunctive therapy.

Journal

Annals of Clinical Psychiatry – Springer Journals

Published: Sep 30, 2004

References

  • Dysphoric mania. Clinical and biological correlates
    Post, RM; Rubinow, DR; Uhde, TW
  • Mixed or dysphoric manic states: psychopathology and treatment
    Swann, AC
  • Bipolar depression: an underestimated treatment challenge
    Hlastala, SA; Frank, E; Mallinger, AG
  • Antidepressant-induced mania and cycle acceleration: a controversy revisited
    Altshuler, LL; Post, RM; Leverich, GS
  • Mania and hypomania during antidepressant pharmacotherapy: Clinical and Research Implications in Neurobiology of Mood Disorders
    Pickar, D; Cowdry, RW; Zis, AP
  • Can antidepressants cause mania and worsen the course of affective illness?
    Wehr, TA; Goodwin, FK
  • Induction of mania with selective serotonin re-uptake inhibitors and tricyclic antidepressants
    Peet, M
  • Antidepressant-associated mania: a controlled comparison with spontaneous mania
    Stoll, AL; Mayer, PV; Kolbrener, M
  • Mixed mania: apparent induction by a tricyclic antidepressant in five consecutively treated patients with bipolar depression
    Dilsaver, SL; Swann, AC
  • Course of illness and maintenance treatments for patients with bipolar disorder
    Solomon, DA; Keitner, GI; Miller, IW
  • Induction of mania with serotonin reuptake inhibitors
    Howland, RH
  • Antidepressant treatment and the course of mania in bipolar patients admitted for depression
    Solomon, RL; Rich, CL; Darko, DF
  • Acute treatment of bipolar depression with gabapentin
    Young, LT; Robb, JC; Patelis-Siotis, I
  • A pilot trial of adjunctive gabapentin in the treatment of bipolar disorder
    McElroy, SL; Soutullo, CA; Keck
  • Efficacy and safety of gabapentin (Neurontin): a multicenter placebo controlled, double-blind study
    Bruni, J; Saunders, M; Anhut, H
  • Gabapentin: A new agent for the management of epilepsy
    Andrews, CO; Fischer, JH
  • Emerging perspectives on the mechanism of action of gabapentin
    Taylor, CP
  • Gabapentin for treatment of bipolar and schizoaffective disorders (letter)
    Bennet, J; Goldman, WT; Suppes, T
  • Gabapentin in bipolar disorder
    Ryback, RS; Brodsky, L; Munasifi, F
  • Gabapentin in the treatment of bipolar disorder (letter)
    Schaffer, CB; Schaffer, LC.
  • Treatment of acute mania with gabapentin (letter)
    Stanton, SP; Keck, PE; McElroy, SL
  • Gabapentin treatment of mood disorders: a preliminary study
    Ghaemi, SN; Katzow, JJ; DeSai, SP; Goodwin, FK
  • Structured Clinical Interview for DSM-IV
    Spitzer, RL; Williams, JBW; Mirron, G
  • Development of a rating scale for primary depressive illness
    Hamilton, M
  • The Bech-Rafaelsen Mania Scale and the Hamilton Depression Scale
    Bech, P; Bolvig, TG; Kramp, P
  • Sleep-loss as a possible mediator of diverse causes of mania
    Wehr, TA
  • Rapid cycling in manic-depressives induced by tricyclic antidepressants
    Wehr, TA; Goodwin, FK
  • The expert consensus guidelines for treating depression in bipolar disorder
    Frances, AJ; Kahn, DA; Carpenter, D
  • Can antidepressants induce rapid cycling?
    Wehr, TA
  • Hypomania induced by gabapentin
    Short, C; Cooke, L