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Gender difference in ranolazine pharmacokinetics in rats

Gender difference in ranolazine pharmacokinetics in rats Pharmacokinetics of ranolazine(RAN) in both female and male rats was studied. RAN concentrations in plasma were determined after oral administration of 12.5,25 and 50 mg/kg RAN. Concentrations in tissues, recoveries of RAN in urine and bile were also analyzed following oral dose of 25 mg/kg. It was found that plasma concentrations of RAN in female rats were significantly higher than those in male rats. Drug exposures based on Cmax and AUC in female rats were roughly 2-to-3-fold of those in male rats. Terminate half-life T1/2 and MRT in male rats were shorter than those in female rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of of Drug Metabolism and Pharmacokinetics Springer Journals

Gender difference in ranolazine pharmacokinetics in rats

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References (11)

Publisher
Springer Journals
Copyright
Copyright © 2003 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Human Physiology; Pharmaceutical Sciences/Technology; Medical Biochemistry
ISSN
0378-7966
eISSN
2107-0180
DOI
10.1007/BF03190499
pmid
12877569
Publisher site
See Article on Publisher Site

Abstract

Pharmacokinetics of ranolazine(RAN) in both female and male rats was studied. RAN concentrations in plasma were determined after oral administration of 12.5,25 and 50 mg/kg RAN. Concentrations in tissues, recoveries of RAN in urine and bile were also analyzed following oral dose of 25 mg/kg. It was found that plasma concentrations of RAN in female rats were significantly higher than those in male rats. Drug exposures based on Cmax and AUC in female rats were roughly 2-to-3-fold of those in male rats. Terminate half-life T1/2 and MRT in male rats were shorter than those in female rats.

Journal

European Journal of of Drug Metabolism and PharmacokineticsSpringer Journals

Published: Aug 3, 2010

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