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Glutathione peroxidase activity is neuroprotective in models of Huntington's disease

Glutathione peroxidase activity is neuroprotective in models of Huntington's disease Flaviano Giorgini and colleagues perform an overexpression screen in yeast to identify genes that can suppress the toxic effects of the mutant Huntington's disease protein Htt. They identify glutathione peroxidase activity as a robust suppressor of mutant Htt toxicity and validate these protective effects in Drosophila and in mammalian cell models. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Genetics Springer Journals

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References (52)

Publisher
Springer Journals
Copyright
Copyright © 2013 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Biomedicine; Biomedicine, general; Human Genetics; Cancer Research; Agriculture; Gene Function; Animal Genetics and Genomics
ISSN
1061-4036
eISSN
1546-1718
DOI
10.1038/ng.2732
Publisher site
See Article on Publisher Site

Abstract

Flaviano Giorgini and colleagues perform an overexpression screen in yeast to identify genes that can suppress the toxic effects of the mutant Huntington's disease protein Htt. They identify glutathione peroxidase activity as a robust suppressor of mutant Htt toxicity and validate these protective effects in Drosophila and in mammalian cell models.

Journal

Nature GeneticsSpringer Journals

Published: Aug 25, 2013

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