Access the full text.
Sign up today, get DeepDyve free for 14 days.
J Breborowicz, A Mackiewicz, D Breborowicz (1981)
Microheterogeneity of α-fetoprotein in patient serum as demonstrated by lectin affino-electrophoresisScand J Immunol, 14
J Henke, S Kellner, D Kasulke (1978)
Haptoglobin- and group-specific component-phenotypes in healthy carriers of antibodies to hepatitis B surface antigenBlut, 36
BP Chatterjee, U Chatterjee, G Mondal (2010)
Changes of serum protein glycosylation as marker in the differential diagnosis of hepatitis and liver cirrhosisProc Natl Acad Sci India, 80
J Miyazaki, Y Endo, T Oda (1981)
Lectin affinities of α-fetoprotein in liver cirrhosis, hepatocellular carcinoma and metastatic liver tumorActa Hepatol Jpn, 22
M Jezequel, NS Seta Corbic, MM Corbic, JM Feger, GM Durand (1988)
Modifications of Concanavalin A patterns of α1 acid glycoprotein and α2-HS glycoprotein in alcoholic liver diseaseClin Chim Acta, 176
FC Liu, DM Chang, JH Lai, CK Lin, HC Chen (2007)
Autoimmune hepatitis with raised alpha-fetoprotein level as the presenting symptoms of systemic lupus erythematosus: a case reportRheumatol Int, 27
S Thompson, BM Cantwell, KL Matta, GA Turner (1992)
Parallel changes in the blood levels of abnormally-fucosylated haptoglobin and alpha (1-3)-l-fucosyl transferase in relationship to tumor burden: more evidence for a disturbance of fucose metabolism in cancerCancer Lett, 65
HB Lee, OJ Yoo, JS Ham, MH Lee (1992)
Serum alpha 1-antitrypsin in patients with hepatocellular carcinomaClin Chim Acta, 206
PK Buamah, C Cornell, AJ Cassells-Smith, AW Skillen (1987)
Differential reactivity of α-fetoprotein with lectins and its usefulness in the diagnosis of various liver diseasesClin Chim Acta, 168
G Mondal, U Chatterjee, YK Chawla, BP Chatterjee (2011)
Alterations of glycan branching and differential expression of sialic acid on alpha fetoprotein among hepatitis patientsGlycoconj J, 28
S Roy, S Biswas, A Saroha, HR Das (2013)
Enhanced expression and fucosylation of ficolin 3 in plasma of RA patientsClin Biochem, 46
M Nakano, T Nakagawa, T Ito, T Kitada, T Hijioka (2008)
Site-specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer: a novel approach for the development of tumor markersInt J Cancer, 122
NS Serbource Goguel Seta, MC Bordas, JA Davy, GM Durand (1984)
Evaluation of the degree of desialylation of serum Ci-inactivator and haemopexinClin Chim Acta, 143
C Sekine, Y Aoyagi, Y Suzuki, F Ichida (1987)
The reactivity of alpha-1-antitrypsin with Lens culinaris agglutinin and its usefulness in the diagnosis of neoplastic diseases of the liverBr J Cancer, 56
N Kinoshita, S Suzuki, Y Matsuda, N Taniguchi (1989)
α-Fetoprotein antibody-lectin enzyme immunoassay to characterize sugar chains for the study of liver diseasesClin Chim Acta, 179
M Borsotti, C Philippis, F Leoncini, F Mazzotta, F Paci (1980)
Changes in the serum protein picture in viral hepatitis. II. Evaluation of the proteins in the acute phaseQuad Sclavo Diagn Clin Lab, 16
K Yamashita, N Koide, T Endo, Y Iwaki, A Kobata (1989)
Altered glycosylation of serum transferrin of patients with hepatocellular carcinomaJ Biol Chem, 264
DG Ward, N Suggett, Y Cheng, W Wei, H Johnson (2006)
Identification of serum biomarkers for colon cancer by proteomic analysisBr J Cancer, 94
KA Kim, EY Lee, JH Kang, HG Lee, JW Kim (2006)
Diagnostic accuracy of serum asialo-alpha1-acid glycoprotein concentration for the differential diagnosis of liver cirrhosis and hepatocellular carcinomaClin Chim Acta, 369
J Ebersole, D Cappelli (2000)
Acute phase protein reactants in infectious and inflammatory diseasesPeriodontology, 2
Y Aoyagi, Y Suzuki, M Isemura, K Soga, T Ozaki (1984)
Differential reactivity of α-fetoprotein with lectins and evaluation of its usefulness in the diagnosis of hepatocellular carcinomaGann, 75
JT Whicher, CI Westacott (1992)
Biochemistry of inflammation
S Kornfeld, ML Reitman, R Kornfeld (1981)
The carbohydrate binding specificity of pea and lentil lectinsJ Biol Chem, 256
A Mackiewicz, T Pawlowski, K Wiktorowicz, S Mackiewicz (1986)
Lectins-biology, biochemistry and clinical biochemistry
A Mackiewicz, R Marcinkowska-Pieta, S Ballou, S Mackiewicz, I Kushner (1987)
Microheterogeneity of α1 acid glycoprotein in the detection of intercurrent infection in systemic lupus erythematousArthritis Rheumatol, 30
R Meliconi, O Parracino, A Facchini, AM Morselli-Labate, F Bortolotti (1988)
Acute phase proteins in chronic and malignant liver diseasesLiver, 8
JM Pekelharing, E Hepp, JP Kamerling, GJ Gerwig, P Leijnse (1988)
Alterations in carbohydrate composition of serum IgG from patients with rheumatoid arthritis and from pregnant womenAnn Rheum Dis, 47
MA Elliott, HG Elliott, K Gallagher, J McGuire, M Field (1997)
Investigation into the Concanavalin A reactivity, fucosylation and oligosaccharide microheterogeneity of α1-acid glycoprotein expressed in the sera of patients with rheumatoid arthritisJ Chromatogr, 688
Y Bacq, Y Schillio, JF Brechot, A Muret, F Dubois (1993)
Decrease of haptoglobulin serum level in patients with chronic hepatitis CGastroenterol Clin Biol, 17
Y Kanoh, T Mashiko, M Danbara, Y Takayama, S Ohtani (2004)
Changes in serum IgG oligosaccharide chains with prostate cancer progressionAnticancer Res, 24
D Biou, D Konan, J Feger, J Agneray, Y Leroy (1987)
Alterations in the carbohydrate moiety of alpha-1 acid glycoproteins purified from human cirrhotic ascetic fluidBiochim Biophys Acta, 913
A Sarrats, R Saldova, E Pla, E Fort, DJ Harvey (2010)
Glycosylation of liver acute-phase proteins in pancreatic cancer and chronic pancreatitisProteomics Clin Appl, 4
JM Koomen, LN Shih, KR Coombes, D Li, LC Xiao (2005)
Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteinsClin Cancer Res, 11
L Kalabay, L Jakab, B Fekete, Z Prohaszka, Z Benko (2002)
Human fetuin/α2HS-glycoprotein level as a novel indicator of liver cell function and short-term mortality in patients with liver cirrhosis and liver cancerEur J Gastroenterol Hepatol, 14
ED Green, JU Baenziger (1989)
Characterization of oligosaccharides by lectin affinity high-performance liquid chromatographyTrends Biochem Sci, 14
K Taketa, C Sekiya, M Namiki, K Akamatsu, Y Ohta (1990)
Lectin-reactive profiles of α-fetoprotein characterizing hepatocellular carcinoma and related conditionsGastroenterology, 99
K Vanarsa, Y Ye, J Han, C Xie, C Mohan, T Wu (2012)
Inflammation associated anemia and ferritin as disease markers in SLEArthritis Res Ther, 14
EV Volchkova, SG Pak, VA Malov, KT Umbetova (2000)
Changes in the levels of acute phase proteins in viral hepatitisTer Arkh, 72
L Kalabay, Z Prohaszka, G Fust, Z Benko, L Telegdy (2005)
Liver cirrhosis: new research
MA Comunale, L Rodemich-Betesh, J Hafner, M Wang, P Norton (2010)
Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinomaPLoS ONE, 5
R Saldova, L Royle, CM Radcliffe, UM Abd Hamid, R Evans (2007)
Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgGGlycobiology, 17
K Taketa, Y Endo, C Sekiya, K Tanikawa, H Taga (1993)
A collaborative study for the evaluation of lectin-reactive α-fetoprotein in early detection of hepatocellular carcinomaCancer Res, 53
RA Feelders, G Vreugdenhil, G Jong, AJG Swaak, HG Eijk (1992)
Transferrin microheterogeneity in rheumatoid arthritisRheumatol Int, 12
TW Graaf, ME Stelt, MG Anbergen, W Dijk (1993)
Inflammation-induced expression of sialyl Lewis X-containing glycan structures on alpha 1-acid glycoprotein (orosomucoid) in human seraJ Exp Med, 177
AJ Rai, Z Zhang, J Rosenzweig, M Shih Ie, T Pham (2002)
Proteomic approaches to tumor marker discoveryArch Pathol Lab Med, 126
A Saroha, S Biswas, BP Chatterjee, HR Das (2011)
Altered glycosylation and expression of plasma alpha-1-acid glycoprotein and haptoglobin in rheumatoid arthritisJ Chromatogr, 879
R Pateva, K Koichev, G Vurbanov, E Rusinov, I Danev (1982)
Complex study of glycoproteins in liver diseaseVutreshni Bolesti, 21
JS Axford, L Mackenzie, PM Lydyard, FC Hay, DA Isenberg (1987)
Reduced B-cell galactosyl transferase activity in rheumatoid arthritisLancet, 2
J Raynes (1982)
Variations in the relative proportions of microheterogeneous forms of plasma glycoproteins in pregnancy and diseaseBiomedicine, 36
G Spik, V Debruyne, J Montreuil (1983)
Structural carbohydrates in the liver
K Shiraki, K Takase, Y Tameda, M Hamada, Y Kosaka (1995)
A clinical study of lectin-reactive α-fetoprotein as an early indicator of hepatocellular carcinoma in the follow-up of cirrhotic patientsHepatology, 22
D Gitlin, A Perricelli, GM Gitlin (1972)
Synthesis of AFP by liver, yolk sac and GI tract of the human conceptionCancer Res, 32
B Ye, DW Cramer, SJ Skates, SP Gygi, V Pratomo (2003)
Haptoglobin-α subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometryClin Cancer Res, 9
I Kushner, A Mackiewicz (1993)
Acute phase proteins: molecular biology, biochemistry and clinical applications
XF Tan, SS Wu, SP Li, Z Chen, F Chen (2011)
Alpha-1 antitrypsin is a potential biomarker for hepatitis BVirol J, 8
ZJ El-Akawi, FK Al-Hindawi, NA Bashir (2008)
Alpha-1 antitrypsin (alpha1-AAT) plasma levels in lung, prostate and breast cancer patientsNeuro Endocrinol Lett, 29
HL Huang, T Stasyk, S Morandell, H Dieplinger, G Falkensammer (2006)
Biomarker discovery in breast cancer serum using 2-D differential gel electrophoresis/MALDI-TOF/TOF and data validation by routine clinical assaysElectrophoresis, 27
T Fujimura, Y Shinohara, B Tissot, PC Pang, M Kurogochi (2008)
Glycosylation status of haptoglobin in sera of patients with prostate cancer vs. benign prostate disease or normal subjectsInt J Cancer, 122
N Okuyama, Y Ide, M Nakano, T Nakagawa, K Yamanaka (2006)
Fucosylated haptoglobin is a novel marker for pancreatic cancer: a detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylationInt J Cancer, 118
AC Mann, CO Record, CH Self, GA Turner (1994)
Monosaccharide composition of haptoglobin in liver-diseases and alcohol-abuse 2 large changes in glycosylation associated with alcoholic liver-diseaseClini Chim Acta, 227
G Mondal, U Chatterjee, HR Das, BP Chatterjee (2009)
Enhanced expression of α1-acid glycoprotein and fucosylation in hepatitis B patients provides an insight into pathogenesisGlycoconj J, 26
KL Abbott, K Aoki, JM Lim, M Porterfield, R Johnson (2008)
Targeted glycoproteomic identification of biomarkers for human breast carcinomaJ Proteome Res, 7
E Dargan, S Thompson, BMJ Cantwell, RG Wilson, GA Turner (1994)
Changes in the fucose content of haptoglobin in breast and ovarian cancer: association with disease progressionGlycoconj J, 1
L Kalabay, F Szalay, E Nemesanszky, L Telegdy, L Jakab (1997)
Decreased serum alfa2-HS-glycoprotein concentration in patients with primary biliary cirrhosisJ Hepatol, 26
L Vaughan, MA Lorier, RW Carrell (1982)
Alpha1-antitrypsin microheterogeneity. Isolation and physiological significance of isoformsBiochim Biophys Acta, 701
T Andersen, L Munthe-Fog, P Garred, S Jacobson (2009)
Serum levels of ficolin-3 (Hakada antigen) in patients with systemic lupus erythematosusJ Rheumatol, 36
S Yoshizawa, K Nagasawa, Y Yae, Y Niho, K Okochi (1997)
A thermolabile α 2-macroglycoprotein (TMG) and the antibody against TMG in patients with systemic lupus erythematosusClin Chim Acta, 264
E Miyoshi, K Noda, Y Yamaguchi, S Inoue, Y Ikeda (1999)
The α 1-6-fucosyltransferase gene and its biological significanceBiochim Biophys Acta, 1473
V Debruyne, J Montreuil, G Spik (1984)
Crossed immunoaffinity electrophoresis of human transferring in normal and cirrhotic seraProtides Biol Fluids Proc Colloq, 31
G Morrone, L Corbo, MC Turco, R Pizzano, M Felice (1988)
Transferrin-like autocrine growth factor, derived from T-lymphoma cells that inhibit normal T-cell proliferationCancer Res, 48
SJ Yoon, SY Park, PC Pang, J Gallagher, JE Gottesman (2010)
N-glycosylation status of beta-haptoglobin in sera of patients with prostate cancer vs. benign prostate diseasesInt J Oncol, 36
RB Parekh, RA Dwek, TW Rademacher (1988)
Rheumatoid arthritis as a glycosylation disorderBr J Rheumatol, 27
W Dijk, C Koeleman, B Hof, D Poland, C Jakobs (2001)
Increased α3-fucosylation of α1-acid glycoprotein in patients with congenital disorder of glycosylation type IA (CDG-Ia)FEBS Lett, 494
K Ishibashi, A Nishikawa, N Hayashi, A Kasahara, N Sato (1989)
N-Acetylglucosaminyltransferase in human serum and liver and hepatoma tissues: increased activity in liver cirrhosis and hepatoma patientsClin Chim Acta, 185
BP Chatterjee, G Mondal, U Chatterjee (2011)
Reactivity of fetoprotein with lectins in the differential diagnosis of non-malignant and malignant liver diseaseTrends Carbohydr Res, 3
KR Kozak, F Su, JP Whitelegge, K Faull, S Reddy (2005)
Characterization of serum biomarkers for detection of early stage ovarian cancerProteomics, 5
PA Ganz, WE Shell, ZA Tokes (1983)
Evaluation of a radioimmunoassay for alpha 1-acid glycoprotein to monitor therapy of cancer patientsJ Natl Cancer Inst, 71
H Baumann, J Gauldie (1994)
The acute phase responseImmunol Today, 15
SY Park, SJ Yoon, YT Jeong, JM Kim, JY Kim (2010)
N-glycosylation status of beta-haptoglobin in sera of patients with colon cancer, chronic inflammatory diseases and normal subjectsInt J Cancer, 126
H Shu, S Zhang, X Kang, S Li, X Qin (2011)
Protein expression and fucosylated glycans of the serum haptoglobin-β subunit in hepatitis B virus-based liver diseasesActa Biochim Biophys, 43
A Mackiewicz, K Mackiewicz (1995)
Glycoforms of serum alpha-1 acid glycoprotein as markers of inflammation and cancerGlycoconj J, 12
PD Eckersall (1995)
Acute phase proteins as markers of inflammatory lesionsComp Haematol Int, 5
T Ishiguro, H Sakaguchi, M Fukui (1986)
Serum alpha-fetoprotein subfractions in hepatic malignancies identified by different reactivities with concanavalin A, lentil lectin or phytohemagglutinin-EJpn J Surg, 16
AS Mehta, RE Long, MA Comunale, M Wang, L Rodemich (2008)
Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosisJ Virol, 82
A Saroha, S Kumar, BP Chatterjee, HR Das (2012)
Jacalin bound plasma O-glycoproteome and reduced sialylation of alpha 2-HS glycoprotein (A2HSG) in rheumatoid arthritis patientsPLoS ONE, 7
SD Shiyan, NV Bovin (1997)
Carbohydrate composition and immunomodulatory activity of different glycoforms of alpha1-acid glycoproteinGlycoconj J, 14
PK Buamah, I Gibb, G Bates, WA Mitford (1984)
Serum alpha fetoprotein heterogeneity as a means of differentiation between primary hepatocellular carcinoma and hepatic secondariesClin Chim Acta, 139
N Serbource-Goguel, M Corbic, S Erlinger, G Durand, J Agneray, J Feger (1983)
Measurement of serum α1 acid glycoprotein and α1-antitrypsin desialylation in liver diseaseHepatology, 3
RB Parekh, IM Roitt, DA Isenberg, RA Dwek, BM Annell (1988)
Galactosylation of IgG associated oligosaccharides: reduction in patients with adult and juvenile onset rheumatoid arthritis and relation to disease activityLancet, 1
IL Ang, TCW Poon, PBS Lai, ATC Chan, SM Ngai (2006)
Study of serum haptoglobin and its glycoforms in the diagnosis of hepatocellular carcinoma: a glycoproteomic approachJ Proteome Res, 5
K Taketa, E Ichikawa, H Taga, H Hirai (1985)
Antibody-affinity blotting, a sensitive technique for the detection of α-fetoprotein separated by lectin affinity electrophoresis in agarose gelsElectrophoresis, 6
N Ahmed, KT Oliva, G Barker, P Hoffmann, S Reeve (2005)
Proteomic tracking of serum protein isoforms as screening biomarkers of ovarian cancerProteomics, 5
M Tomana, RE Schrohenloher, WJ Koopman, GS Alarcon, WA Paul (1988)
Abnormal glycosylation of serum IgG from patients with chronic inflammatory diseasesArthritis Rheum, 31
T Hada, M Kondo, K Yasukawa, Y Amuro, K Higashino (1999)
Discrimination of liver cirrhosis from chronic hepatitis by measuring the ratio of Aleuria aurantia lectin-reactive serum cholinesterase to immunoreactive proteinClin Chim Acta, 281
S Hashimoto, T Asao, J Takahashi, Y Yagihashi, T Nishimura (2004)
Alpha1-acid glycoprotein fucosylation as a marker of carcinoma progression and prognosisCancer, 101
Y Sato, K Nakata, Y Kato, M Shima, N Ishii (1993)
Early recognition of hepatocellular carcinoma based on altered profiles of α-fetoproteinN Engl J Med, 328
D Ball, E Rose, E Alpert (1992)
Alpha-fetoprotein levels in normal adultsAm J Med Sci, 303
K Matsumoto, Y Maeda, S Kato, H Yuki (1994)
Alteration of asparagine-linked glycosylation in serum transferrin of patients with hepatocellular carcinomaClin Chim Acta, 224
M Vostrejs, PL Moran, PA Seligman (1988)
Transferrin synthesis by small cell lung cancer cells acts as an autocrine regulator of cellular proliferationJ Clin Invest, 82
EC Brinkman-van der Linden, PF Haan, EC Havenaar, W Dijk (1998)
Inflammation induced expression of sialyl lewis (x) is not restricted to alpha-1 acid glycoprotein but also occurs to a lesser extent on alpha-1-antichymotrypsin and haptoglobinGlycoconj J, 15
S Eriksson, J Carlson, R Velez (1986)
Risk of cirrhosis and primary liver cancer in alpha 1-antitrypsin deficiencyN Engl J Med, 314
T Fukutomi, B Ando, S Sakamoto, H Sakai, H Nawata (1996)
Thermolabile α 2-macroglycoprotein (Hakata antigen) in liver disease: biochemical and immunological studyClin Chim Acta, 255
F Mullinax, AJ Hynes, GL Mullinax (1976)
Molecular site and enzymatic origin of IgG galactose deficiency in rheumatoid arthritis and SLE (abstract)Arthritis Rheum, 19
Y Aoyagi, Y Suzuki, K Igarashi, A Saitoh, M Oguro (1991)
The usefulness of simultaneous determinations of glucosaminylation and fucosylation induces of α-fetoprotein in the differential diagnosis of neoplastic diseases of the liverCancer, 67
PT Gomme, KB McCann, J Bertolini (2005)
Transferrin: structure, function and potential therapeutic actionsDrug Discov Today, 10
RB Parekh, RA Dwek, BJ Sutton (1985)
Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgGNature, 316
MC Bordas, N Serbource-Goguel Seta, JM Feger, JM Maccario (1982)
Evaluation of the degree of desialylation of serum α1 acid glycoprotein and α-1 antitrypsinClin Chim Acta, 120
MT Goodarzi, GA Turner (1995)
Decreased branching, increased fucosylation and changed sialylation of alpha-1-proteinase inhibitor in breast and ovarian cancerClin Chim Acta, 236
All diseases including autoimmune diseases, chronic liver diseases and cancer are a serious health problem worldwide. The current gold standard to assess malignant changes in cells and structural liver damage is through a biopsy, which has several disadvantages. A non-invasive simple test to diagnose malignancy and liver pathology would be highly desirable. Protein glycosylation has drawn the attention of many researchers with an aim to achieve this goal. Glycosylation is the post-translational modification of many secreted proteins and it has been known for decades that structural changes in the glycan structures of serum proteins are an indication of carcinogenesis and liver damage. The aim of this paper is to give an overview of the altered protein glycosylation in different etiologies of liver diseases, autoimmune diseases, and cancer. Although individual carcinoma and liver diseases have their own specific markers, the same alteration seems to reappear continuously in all malignant transformation and liver diseases like hyperfucosylation, sialylation, increased branching and bisecting N-acetylglucosamine.
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences – Springer Journals
Published: Apr 10, 2014
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.