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High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi

High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi Isolates of Salmonella enterica serovar Typhi (Typhi), a human-restricted bacterial pathogen that causes typhoid, show limited genetic variation. Kathryn Holt and colleagues now compare whole-genome sequences of 19 Typhi isolates dispersed throughout the phylogenetic tree of this pathogen, revealing notably little evidence of purifying selection, antigenic variation or recombination between isolates. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Genetics Springer Journals

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References (41)

Publisher
Springer Journals
Copyright
Copyright © Springer Nature America, Inc. 2008
Subject
Biomedicine; Biomedicine, general; Human Genetics; Cancer Research; Agriculture; Gene Function; Animal Genetics and Genomics
ISSN
1061-4036
eISSN
1546-1718
DOI
10.1038/ng.195
Publisher site
See Article on Publisher Site

Abstract

Isolates of Salmonella enterica serovar Typhi (Typhi), a human-restricted bacterial pathogen that causes typhoid, show limited genetic variation. Kathryn Holt and colleagues now compare whole-genome sequences of 19 Typhi isolates dispersed throughout the phylogenetic tree of this pathogen, revealing notably little evidence of purifying selection, antigenic variation or recombination between isolates.

Journal

Nature GeneticsSpringer Journals

Published: Aug 1, 2008

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