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References (43)
-
(2019)
National Library of Medicine, NCBI -
E. Beard (2001)
The American Society of Health System Pharmacists.JONA'S healthcare law, ethics and regulation, 3 3
-
What Is an Allogeneic Stem Cell Transplant? -
(Rajendran S, Gupta PK, Hiremath L, Kumar SN, Srivastava AK (2019) An update on effective patient monitoring and diagnosis of diseases in the current scenario. Recent advances in computational intelligence. vol 823, pp 199–214. Springer, Berlin. https://doi.org/10.1007/978-3-030-12500-4_11)
Rajendran S, Gupta PK, Hiremath L, Kumar SN, Srivastava AK (2019) An update on effective patient monitoring and diagnosis of diseases in the current scenario. Recent advances in computational intelligence. vol 823, pp 199–214. Springer, Berlin. https://doi.org/10.1007/978-3-030-12500-4_11Rajendran S, Gupta PK, Hiremath L, Kumar SN, Srivastava AK (2019) An update on effective patient monitoring and diagnosis of diseases in the current scenario. Recent advances in computational intelligence. vol 823, pp 199–214. Springer, Berlin. https://doi.org/10.1007/978-3-030-12500-4_11, Rajendran S, Gupta PK, Hiremath L, Kumar SN, Srivastava AK (2019) An update on effective patient monitoring and diagnosis of diseases in the current scenario. Recent advances in computational intelligence. vol 823, pp 199–214. Springer, Berlin. https://doi.org/10.1007/978-3-030-12500-4_11
-
(Andrea Rubbert, Georg Behrens, Mario Ostrowski (2011). Pathogenesis of HIV-1 Infection. Published in hivbook.com. https://www.hivbook.com/2011/10/28/3-pathogenesis-of-hiv-1-infection/. Accessed 18 Aug 2019.)
Andrea Rubbert, Georg Behrens, Mario Ostrowski (2011). Pathogenesis of HIV-1 Infection. Published in hivbook.com. https://www.hivbook.com/2011/10/28/3-pathogenesis-of-hiv-1-infection/. Accessed 18 Aug 2019.Andrea Rubbert, Georg Behrens, Mario Ostrowski (2011). Pathogenesis of HIV-1 Infection. Published in hivbook.com. https://www.hivbook.com/2011/10/28/3-pathogenesis-of-hiv-1-infection/. Accessed 18 Aug 2019., Andrea Rubbert, Georg Behrens, Mario Ostrowski (2011). Pathogenesis of HIV-1 Infection. Published in hivbook.com. https://www.hivbook.com/2011/10/28/3-pathogenesis-of-hiv-1-infection/. Accessed 18 Aug 2019.
-
P. Lemey, Sergei Pond, A. Drummond, O. Pybus, B. Shapiro, H. Barroso, N. Taveira, A. Rambaut (2007)
Synonymous Substitution Rates Predict HIV Disease Progression as a Result of Underlying Replication DynamicsPLoS Computational Biology, 3
-
(CCR5 gene. Genetics Home Reference. U. S. National Library of Medicine. https://ghr.nlm.nih.gov/gene/CCR5. Accessed 18 Aug 2019)
CCR5 gene. Genetics Home Reference. U. S. National Library of Medicine. https://ghr.nlm.nih.gov/gene/CCR5. Accessed 18 Aug 2019CCR5 gene. Genetics Home Reference. U. S. National Library of Medicine. https://ghr.nlm.nih.gov/gene/CCR5. Accessed 18 Aug 2019, CCR5 gene. Genetics Home Reference. U. S. National Library of Medicine. https://ghr.nlm.nih.gov/gene/CCR5. Accessed 18 Aug 2019
-
M. Santoro, C. Perno (2013)
HIV-1 Genetic Variability and Clinical ImplicationsISRN Microbiology, 2013
-
T. Brown (2020)
The London Patient.AIDS research and human retroviruses
-
G. Alkhatib (2009)
The biology of CCR5 and CXCR4Current Opinion in HIV and AIDS, 4
-
(The Basics of HIV Prevention (2019). AIDS info. U. S. Department of Health and Human Services. https://aidsinfo.nih.gov/understanding-hiv-aids/fact-sheets/20/48/the-basics-of-hiv-prevention. Accessed 20 Aug 2019)
The Basics of HIV Prevention (2019). AIDS info. U. S. Department of Health and Human Services. https://aidsinfo.nih.gov/understanding-hiv-aids/fact-sheets/20/48/the-basics-of-hiv-prevention. Accessed 20 Aug 2019The Basics of HIV Prevention (2019). AIDS info. U. S. Department of Health and Human Services. https://aidsinfo.nih.gov/understanding-hiv-aids/fact-sheets/20/48/the-basics-of-hiv-prevention. Accessed 20 Aug 2019, The Basics of HIV Prevention (2019). AIDS info. U. S. Department of Health and Human Services. https://aidsinfo.nih.gov/understanding-hiv-aids/fact-sheets/20/48/the-basics-of-hiv-prevention. Accessed 20 Aug 2019
-
Fatima Barmania, M. Pepper (2013)
C-C chemokine receptor type five (CCR5): An emerging target for the control of HIV infection☆Applied & Translational Genomics, 2
-
M. Sankaranantham (2019)
HIV – Is a cure possible?Indian Journal of Sexually Transmitted Diseases and AIDS, 40
-
(CROI 2017: Timothy Brown, The Berlin Patient, Celebrates A Decade Cured of HIV (2017). VI Western Europe and Central Asia AIDS Conference, Moscow, Russia. http://en.eecaac2018.org/world/croi-2017-timothy-brown-the-berlin-patient-celebrates-a-decade-cured-of-hiv/. Accessed 18 Aug 2019)
CROI 2017: Timothy Brown, The Berlin Patient, Celebrates A Decade Cured of HIV (2017). VI Western Europe and Central Asia AIDS Conference, Moscow, Russia. http://en.eecaac2018.org/world/croi-2017-timothy-brown-the-berlin-patient-celebrates-a-decade-cured-of-hiv/. Accessed 18 Aug 2019CROI 2017: Timothy Brown, The Berlin Patient, Celebrates A Decade Cured of HIV (2017). VI Western Europe and Central Asia AIDS Conference, Moscow, Russia. http://en.eecaac2018.org/world/croi-2017-timothy-brown-the-berlin-patient-celebrates-a-decade-cured-of-hiv/. Accessed 18 Aug 2019, CROI 2017: Timothy Brown, The Berlin Patient, Celebrates A Decade Cured of HIV (2017). VI Western Europe and Central Asia AIDS Conference, Moscow, Russia. http://en.eecaac2018.org/world/croi-2017-timothy-brown-the-berlin-patient-celebrates-a-decade-cured-of-hiv/. Accessed 18 Aug 2019
-
Johanna Smith, R. Daniel (2006)
Following the path of the virus: the exploitation of host DNA repair mechanisms by retroviruses.ACS chemical biology, 1 4
-
CCR5-delta 32: The rare mutation that could help stop HIV. Project UPSC-wordpress -
(Jon Cohen (2020). Second ‘cured’ HIV patient goes public. Science Magazine. https://www.sciencemag.org/news/2020/03/second-cured-hiv-patient-goes-public. Accessed 5 Jan 2021)
Jon Cohen (2020). Second ‘cured’ HIV patient goes public. Science Magazine. https://www.sciencemag.org/news/2020/03/second-cured-hiv-patient-goes-public. Accessed 5 Jan 2021Jon Cohen (2020). Second ‘cured’ HIV patient goes public. Science Magazine. https://www.sciencemag.org/news/2020/03/second-cured-hiv-patient-goes-public. Accessed 5 Jan 2021, Jon Cohen (2020). Second ‘cured’ HIV patient goes public. Science Magazine. https://www.sciencemag.org/news/2020/03/second-cured-hiv-patient-goes-public. Accessed 5 Jan 2021
-
(Santoro MM, Perno CF. HIV-1 Genetic Variability and Clinical Implications. ISRN Microbiol. 2013;2013:481314. Published 2013 Jun 17. doi:10.1155/2013/481314.ISBN 978-3-030-12500-4)
Santoro MM, Perno CF. HIV-1 Genetic Variability and Clinical Implications. ISRN Microbiol. 2013;2013:481314. Published 2013 Jun 17. doi:10.1155/2013/481314.ISBN 978-3-030-12500-4Santoro MM, Perno CF. HIV-1 Genetic Variability and Clinical Implications. ISRN Microbiol. 2013;2013:481314. Published 2013 Jun 17. doi:10.1155/2013/481314.ISBN 978-3-030-12500-4, Santoro MM, Perno CF. HIV-1 Genetic Variability and Clinical Implications. ISRN Microbiol. 2013;2013:481314. Published 2013 Jun 17. doi:10.1155/2013/481314.ISBN 978-3-030-12500-4
-
M. Velasco-Velázquez, X. Jiao, M. Fuente, Timothy Pestell, A. Ertel, M. Lisanti, R. Pestell (2012)
CCR5 antagonist blocks metastasis of basal breast cancer cells.Cancer research, 72 15
-
R. Yarchoan, H. Mitsuya, C. Myers, S. Broder (1989)
Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides.The New England journal of medicine, 321 11
-
(Health Team (2019). What Is an Allogeneic Stem Cell Transplant? Wellness Destination India. https://www.wellnessdestinationindia.com/allogeneic-bone-marrow-or-stem-cell-transplant-cost-in-india/. Accessed 18 Aug 2019)
Health Team (2019). What Is an Allogeneic Stem Cell Transplant? Wellness Destination India. https://www.wellnessdestinationindia.com/allogeneic-bone-marrow-or-stem-cell-transplant-cost-in-india/. Accessed 18 Aug 2019Health Team (2019). What Is an Allogeneic Stem Cell Transplant? Wellness Destination India. https://www.wellnessdestinationindia.com/allogeneic-bone-marrow-or-stem-cell-transplant-cost-in-india/. Accessed 18 Aug 2019, Health Team (2019). What Is an Allogeneic Stem Cell Transplant? Wellness Destination India. https://www.wellnessdestinationindia.com/allogeneic-bone-marrow-or-stem-cell-transplant-cost-in-india/. Accessed 18 Aug 2019
-
(Team SSARP (2019). CCR5-delta 32: The rare mutation that could help stop HIV. Project UPSC- wordpress.com. https://projectupsc.wordpress.com/2019/03/09/ccr5-delta-32-the-rare-mutation-that-could-help-stop-hiv/. Accessed 18 Aug 2019)
Team SSARP (2019). CCR5-delta 32: The rare mutation that could help stop HIV. Project UPSC- wordpress.com. https://projectupsc.wordpress.com/2019/03/09/ccr5-delta-32-the-rare-mutation-that-could-help-stop-hiv/. Accessed 18 Aug 2019Team SSARP (2019). CCR5-delta 32: The rare mutation that could help stop HIV. Project UPSC- wordpress.com. https://projectupsc.wordpress.com/2019/03/09/ccr5-delta-32-the-rare-mutation-that-could-help-stop-hiv/. Accessed 18 Aug 2019, Team SSARP (2019). CCR5-delta 32: The rare mutation that could help stop HIV. Project UPSC- wordpress.com. https://projectupsc.wordpress.com/2019/03/09/ccr5-delta-32-the-rare-mutation-that-could-help-stop-hiv/. Accessed 18 Aug 2019
-
(Vincent Racaniello (2019). The London Patient. Virology blog. http://www.virology.ws/2019/03/13/the-london-patient/. Accessed 19 Aug 2019)
Vincent Racaniello (2019). The London Patient. Virology blog. http://www.virology.ws/2019/03/13/the-london-patient/. Accessed 19 Aug 2019Vincent Racaniello (2019). The London Patient. Virology blog. http://www.virology.ws/2019/03/13/the-london-patient/. Accessed 19 Aug 2019, Vincent Racaniello (2019). The London Patient. Virology blog. http://www.virology.ws/2019/03/13/the-london-patient/. Accessed 19 Aug 2019
-
D. Ghosh, Prabhadevi Venkataramani, Saikat Nandi, S. Bhattacharjee (2019)
CRISPR–Cas9 a boon or bane: the bumpy road ahead to cancer therapeuticsCancer Cell International, 19
-
(Zidovudine. The American Society of Health-System Pharmacists. Archived from the original on December 21, 2016. Retrieved November 28, 2016. https://www.drugs.com/monograph/zidovudine.html. Accessed 19 August 2019.)
Zidovudine. The American Society of Health-System Pharmacists. Archived from the original on December 21, 2016. Retrieved November 28, 2016. https://www.drugs.com/monograph/zidovudine.html. Accessed 19 August 2019.Zidovudine. The American Society of Health-System Pharmacists. Archived from the original on December 21, 2016. Retrieved November 28, 2016. https://www.drugs.com/monograph/zidovudine.html. Accessed 19 August 2019., Zidovudine. The American Society of Health-System Pharmacists. Archived from the original on December 21, 2016. Retrieved November 28, 2016. https://www.drugs.com/monograph/zidovudine.html. Accessed 19 August 2019.
-
S. Rajendran, M. Vakil, P. Gupta, Lingayya Hiremath, S. Kumar, A. Srivastava, V. Shree (2019)
An Update on Effective Patient Monitoring and Diagnosis of Diseases in the Current Scenario -
Michele Tang, R. Shafer (2012)
HIV-1 Antiretroviral ResistanceDrugs, 72
-
J. Weber (2001)
The pathogenesis of HIV-1 infection.British medical bulletin, 58
-
(Thumbi Ndung’u (2017). Four big insights into HIV/AIDS that provide hope of finding a vaccine. The Conversation. https://theconversation.com/four-big-insights-into-hiv-aids-that-provide-hope-of-finding-a-vaccine-86736. Accessed 18 Aug 2019.)
Thumbi Ndung’u (2017). Four big insights into HIV/AIDS that provide hope of finding a vaccine. The Conversation. https://theconversation.com/four-big-insights-into-hiv-aids-that-provide-hope-of-finding-a-vaccine-86736. Accessed 18 Aug 2019.Thumbi Ndung’u (2017). Four big insights into HIV/AIDS that provide hope of finding a vaccine. The Conversation. https://theconversation.com/four-big-insights-into-hiv-aids-that-provide-hope-of-finding-a-vaccine-86736. Accessed 18 Aug 2019., Thumbi Ndung’u (2017). Four big insights into HIV/AIDS that provide hope of finding a vaccine. The Conversation. https://theconversation.com/four-big-insights-into-hiv-aids-that-provide-hope-of-finding-a-vaccine-86736. Accessed 18 Aug 2019.
-
Daniela Sicoli, X. Jiao, Xiaoming Ju, M. Velasco-Velázquez, A. Ertel, S. Addya, Zhiping Li, S. Andò, A. Fatatis, Bishnuhari Paudyal, M. Cristofanilli, M. Thakur, M. Lisanti, R. Pestell (2014)
CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines.Cancer research, 74 23
-
P. Gupta, V. Shree, Lingayya Hiremath, S. Rajendran (2019)
The Use of Modern Technology in Smart Waste Management and Recycling: Artificial Intelligence and Machine Learning -
(Leila Haghighat, Amrit K. Kamboj (2019). The ‘London Patient’ goes into HIV remission: Here’s what that means for HIV treatment. abc News. https://abcnews.go.com/Health/london-patient-hiv-remission-means-hiv-treatment/story?id=61564150. Accessed 19 Aug 2019)
Leila Haghighat, Amrit K. Kamboj (2019). The ‘London Patient’ goes into HIV remission: Here’s what that means for HIV treatment. abc News. https://abcnews.go.com/Health/london-patient-hiv-remission-means-hiv-treatment/story?id=61564150. Accessed 19 Aug 2019Leila Haghighat, Amrit K. Kamboj (2019). The ‘London Patient’ goes into HIV remission: Here’s what that means for HIV treatment. abc News. https://abcnews.go.com/Health/london-patient-hiv-remission-means-hiv-treatment/story?id=61564150. Accessed 19 Aug 2019, Leila Haghighat, Amrit K. Kamboj (2019). The ‘London Patient’ goes into HIV remission: Here’s what that means for HIV treatment. abc News. https://abcnews.go.com/Health/london-patient-hiv-remission-means-hiv-treatment/story?id=61564150. Accessed 19 Aug 2019
-
P. Murphy (2001)
Viral exploitation and subversion of the immune system through chemokine mimicryNature Immunology, 2
-
KA Sepkowitz (2001)
1764N Engl J Med, 344
-
P. Gilbert, I. McKeague, G. Eisen, Christopher Mullins, A. Guéye-Ndiaye, S. Mboup, P. Kanki (2003)
Comparison of HIV‐1 and HIV‐2 infectivity from a prospective cohort study in SenegalStatistics in Medicine, 22
-
T. Brown (2015)
I am the Berlin patient: a personal reflection.AIDS research and human retroviruses, 31 1
-
P. Mercié (2001)
[AIDS--the first 20 years].La Revue de medecine interne, 22 11
-
Second 'cured' HIV patient goes public. Science Magazine -
J. Alimonti, T. Ball, K. Fowke (2003)
Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS.The Journal of general virology, 84 Pt 7
-
Michele Tang, R. Shafer (2012)
HIV-1 Antiretroviral Resistance Scientific Principles and Clinical Applications -
(Zidovudine. U S National Library of Medicine, NCBI. PubChem. Accessed August 18 2019. https://pubchem.ncbi.nlm.nih.gov/compound/Zidovudine.)
Zidovudine. U S National Library of Medicine, NCBI. PubChem. Accessed August 18 2019. https://pubchem.ncbi.nlm.nih.gov/compound/Zidovudine.Zidovudine. U S National Library of Medicine, NCBI. PubChem. Accessed August 18 2019. https://pubchem.ncbi.nlm.nih.gov/compound/Zidovudine., Zidovudine. U S National Library of Medicine, NCBI. PubChem. Accessed August 18 2019. https://pubchem.ncbi.nlm.nih.gov/compound/Zidovudine.
-
(2017)
Four big insights into HIV/AIDS that provide hope of finding a vaccine -
Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
- Publisher
- Springer Journals
- Copyright
- Copyright © The National Academy of Sciences, India 2021
- ISSN
- 0369-8211
- eISSN
- 2250-1746
- DOI
- 10.1007/s40011-021-01237-y
- Publisher site
- See Article on Publisher Site
Abstract
CCR5-delta 32 homozygous stem cell transplantation for HIV-infected individuals is being treated as a milestone in the global AIDS epidemic. Since 2008, when the second Berlin patient was cured from HIV after undergoing transplantation from a donor with delta-32 mutation, scientists are aiming for a long-term cure for the wider population. In 2019, a London patient became the second person to be free of HIV and came off the antiretroviral drugs completely. CCR5 gene is now being treated as a viable target for HIV treatment. It can be used in the treatment of HIV either through administration of drugs that bind to CCR5 and stop the receptor from working or through gene therapy to alter the CCR5 gene using CRISPR/Cas9 and prevent protein production. This review article aims to identify the obstacles and the need to overcome them in order to bridge the gap between current research and future potential cures for HIV.
Journal
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences – Springer Journals
Published: Sep 1, 2021
Keywords: CCR5-delta 32; Homozygous; AIDS; HIV; Berlin patient; London patient; Drugs; CRISPR/Cas9