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IL-10 −1082 G>A: a risk for prostate cancer but may be protective against progression of prostate cancer in North Indian cohort

IL-10 −1082 G>A: a risk for prostate cancer but may be protective against progression of prostate... World J Urol (2009) 27:389–396 DOI 10.1007/s00345-008-0361-1 ORIGINAL ARTI C L E IL-10 ¡1082 G>A: a risk for prostate cancer but may be protective against progression of prostate cancer in North Indian cohort Pravin Kesarwani · Dinesh Kumar Ahirwar · Anil Mandhani · Anand Narayan Singh · Divakar Dalela · Anand Narain Srivastava · Rama D. Mittal Received: 3 July 2008 / Accepted: 28 November 2008 / Published online: 15 January 2009 © Springer-Verlag 2008 Abstract Conclusion Our results support the emerging hypothesis Background Chronic intraprostatic inXammation is sus- that genetically determined immune activity may play a pected to play a major role in the pathogenesis of prostate role in the pathophysiology of PCa. Our Wndings of high cancer (PCa). Polymorphisms in interleukin-10 (IL-10), a producer of IL-10 ¡1082 variants suggest initiation of PCa. key anti-inXammatory cytokine gene can inXuence immune Future studies in large cohort of diVerent ethnicity PCa response and immune evasion of tumor cells. Its role as an groups are warranted to establish deWnite associations with anti-metastatic molecule is also well documented. other cytokine gene polymorphisms. Methods Gene promoter polymorphisms in IL-10 (¡1082 G>A and ¡819 C>T) was analyzed in 159 PCa Keywords IL-10 · Gene http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png World Journal of Urology Springer Journals

IL-10 −1082 G>A: a risk for prostate cancer but may be protective against progression of prostate cancer in North Indian cohort

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References (32)

Publisher
Springer Journals
Copyright
Copyright © 2008 by Springer-Verlag
Subject
Medicine & Public Health; Urology; Nephrology; Oncology
ISSN
0724-4983
eISSN
1433-8726
DOI
10.1007/s00345-008-0361-1
pmid
19145440
Publisher site
See Article on Publisher Site

Abstract

World J Urol (2009) 27:389–396 DOI 10.1007/s00345-008-0361-1 ORIGINAL ARTI C L E IL-10 ¡1082 G>A: a risk for prostate cancer but may be protective against progression of prostate cancer in North Indian cohort Pravin Kesarwani · Dinesh Kumar Ahirwar · Anil Mandhani · Anand Narayan Singh · Divakar Dalela · Anand Narain Srivastava · Rama D. Mittal Received: 3 July 2008 / Accepted: 28 November 2008 / Published online: 15 January 2009 © Springer-Verlag 2008 Abstract Conclusion Our results support the emerging hypothesis Background Chronic intraprostatic inXammation is sus- that genetically determined immune activity may play a pected to play a major role in the pathogenesis of prostate role in the pathophysiology of PCa. Our Wndings of high cancer (PCa). Polymorphisms in interleukin-10 (IL-10), a producer of IL-10 ¡1082 variants suggest initiation of PCa. key anti-inXammatory cytokine gene can inXuence immune Future studies in large cohort of diVerent ethnicity PCa response and immune evasion of tumor cells. Its role as an groups are warranted to establish deWnite associations with anti-metastatic molecule is also well documented. other cytokine gene polymorphisms. Methods Gene promoter polymorphisms in IL-10 (¡1082 G>A and ¡819 C>T) was analyzed in 159 PCa Keywords IL-10 · Gene

Journal

World Journal of UrologySpringer Journals

Published: Jan 15, 2009

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