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Il danno vascolare nella sclerosi sistemica

Il danno vascolare nella sclerosi sistemica Systemic sclerosis (SSc) is an autoimmune connective tissue disease that involves skin and internal organs. Vascular abnormalities play a key role in the pathogenesis of the disease. Specifically, endothelial derangement with disruption of the normal architecture of the vessels is a specific finding in patients with SSc and is responsible for the tissue chronic ischemia which can manifest clinically as skin ulcers. Although an extensive body of literature supports the pathogenic importance of SSc, the real mechanisms leading to the scleroderma vasculopathy are not known. Besides defective angiogenesis, recent studies suggest that vasculogenesis is also impaired in SSc patients, with decreased numbers of endothelial progenitor cells. Further studies are needed to confirm these pathogenic hypotheses and to suggest new therapeutic approaches for the treatment of SSc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archivio di Ortopedia e Reumatologia Springer Journals

Il danno vascolare nella sclerosi sistemica

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Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer-Verlag Italia
Subject
Medicine & Public Health; Orthopedics
ISSN
0390-7368
eISSN
1592-7113
DOI
10.1007/s10261-010-0006-y
Publisher site
See Article on Publisher Site

Abstract

Systemic sclerosis (SSc) is an autoimmune connective tissue disease that involves skin and internal organs. Vascular abnormalities play a key role in the pathogenesis of the disease. Specifically, endothelial derangement with disruption of the normal architecture of the vessels is a specific finding in patients with SSc and is responsible for the tissue chronic ischemia which can manifest clinically as skin ulcers. Although an extensive body of literature supports the pathogenic importance of SSc, the real mechanisms leading to the scleroderma vasculopathy are not known. Besides defective angiogenesis, recent studies suggest that vasculogenesis is also impaired in SSc patients, with decreased numbers of endothelial progenitor cells. Further studies are needed to confirm these pathogenic hypotheses and to suggest new therapeutic approaches for the treatment of SSc.

Journal

Archivio di Ortopedia e Reumatologia – Springer Journals

Published: Jan 10, 2011

References

  • Scleroderma
    Gabrielli, A.; Avvedimento, E.V.; Krieg, T.
  • Scleroderma: from cell and molecular mechanisms to disease models
    Abraham, D.J.; Varga, J.
  • Raynaud phenomenon and the vascular disease in scleroderma
    Kahaleh, M.B.
  • Sequential dermal microvascular and perivascular changes in the development of scleroderma
    Prescott, R.J.; Freemont, A.J.; Jones, C.J.
  • Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma
    Sgonc, R.; Gruschwitz, M.S.; Dietrich, H.
  • The vascular perspective of systemic sclerosis: of chickens, mice and men
    Sgonc, R.
  • The effects of scleroderma serum on human microvascular endothelial cells. Induction of antibodydependent cellular cytotoxicity
    Marks, R.M.; Czerniecki, M.; Andrews, B.S.; Penny, R.
  • The binding of some human antiendothelial cell antibodies induces endothelial cell apoptosis
    Bordron, A.; Dueymes, M.; Levy, Y.
  • Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95
    Sgonc, R.; Gruschwitz, M.S.; Boeck, G.
  • In vivo analysis of the apoptosis-inducing effect of anti-endothelial cell antibodies in systemic sclerosis by the chorionallantoic membrane assay
    Worda, M.; Sgonc, R.; Dietrich, H.
  • Induction of apopto apoptosis and fibrillin 1 expression in human dermal endothelial cells by scleroderma sera containing anti-endothelial cell antibodies
    Ahmed, S.S.; Tan, F.K.; Arnett, F.C.
  • Vascular repair by endothelial progenitor cells
    Zampetaki, A.; Kirton, J.P.; Xu, Q.
  • Defective vasculogenesis in systemic sclerosis
    Kuwana, M.; Okazaki, Y.; Yasuoka, H.
  • Bone marrow endothelial progenitors are defective in systemic sclerosis
    Papa, N.; Quirici, N.; Soligo, D.
  • Levels of circulating endothelial progenitor cells in systemic sclerosis
    Allanore, Y.; Batteux, F.; Avouac, J.
  • Circulating endothelial progenitor cells in systemic sclerosis: relation to impaired angiogenesis and cardiovascular manifestations
    Nevskaya, T.; Bykovskaia, S.; Lyssuk, E.
  • Simvastatin reduces endothelial activation and damage but is partially ineffective in inducing endothelial repair in systemic sclerosis
    Papa, N.; Cortiana, M.; Vitali, C.
  • Non organ based laboratory markers in systemic sclerosis
    McHugh, N.J.; Distler, O.; Giacomelli, R.; Riemekasten, G.
  • Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)
    Scheja, A.; Akesson, A.; Geborek, P.
  • Electron microscopy and capillaroscopically guided nailfold biopsy in connective tissue diseases: detection of ultrastructural changes of the microcirculatory vessels
    Bierbrauer, A.; Barth, P.; Willert, J.
  • Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis
    Distler, J.H.; Wenger, R.H.; Gassmann, M.
  • Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers
    Distler, O.; Rosso, A.; Giacomelli, R.
  • Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis
    Distler, O.; Distler, J.H.; Scheid, A.
  • Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy
    Dor, Y.; Djonov, V.; Abramovitch, R.
  • Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis
    D’Alessio, S.; Fibbi, G.; Cinelli, M.
  • Adult “endothelial progenitor cells”. Renewing vasculature
    Zammaretti, P.; Zisch, A.H.
  • New insights in vascular development: vasculogenesis and endothelial progenitor cells
    Kaessmeyer, S.; Plendl, J.; Custodis, P.; Bahramsoltani, M.
  • Potential benefit of statins for vascular disease in systemic sclerosis
    Kuwana, M.
  • Circulating endothelial cells as a marker of ongoing vascular disease in systemic sclerosis
    Papa, N.; Colombo, G.; Fracchiolla, N.