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Implementation of an Interferon-Gamma Release Assay to Screen for Tuberculosis in Refugees and Immigrants

Implementation of an Interferon-Gamma Release Assay to Screen for Tuberculosis in Refugees and... Despite increased use and accuracy of interferon-gamma release assays to detect latent tuberculosis infection (LTBI) in foreign-born arrivals in the United States, risk characteristics associated with positive results are not well characterized. We conducted a retrospective record review of 541 refugees and immigrants screened for LTBI with QuantiFERON®-TB Gold In-Tube (QFT-IT) at the Spokane Public Health Clinic from January 2, 2008, through June 5, 2009. Overall, 24 % of the arrivals had a positive QFT-IT, with the greatest frequency of positive results occurring in arrivals from Liberia (100 %) and Bhutan (39 %). More than the expected number of Burmese had indeterminate QFT-IT results. A positive QFT-IT was associated with age, race, ethnicity, and extent of TB burden in the country of origin. QFT-IT is useful to screen for LTBI in foreign-born arrivals, particularly middle-aged adults from high-burden countries. However, the QFT-IT may not yield meaningful results in groups with significant immunocompromise. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Immigrant and Minority Health Springer Journals

Implementation of an Interferon-Gamma Release Assay to Screen for Tuberculosis in Refugees and Immigrants

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References (27)

Publisher
Springer Journals
Copyright
Copyright © 2012 by Springer Science+Business Media New York
Subject
Medicine & Public Health; Public Health; Sociology, general; Private International Law, International & Foreign Law, Comparative Law
ISSN
1557-1912
eISSN
1557-1920
DOI
10.1007/s10903-012-9748-6
pmid
23179470
Publisher site
See Article on Publisher Site

Abstract

Despite increased use and accuracy of interferon-gamma release assays to detect latent tuberculosis infection (LTBI) in foreign-born arrivals in the United States, risk characteristics associated with positive results are not well characterized. We conducted a retrospective record review of 541 refugees and immigrants screened for LTBI with QuantiFERON®-TB Gold In-Tube (QFT-IT) at the Spokane Public Health Clinic from January 2, 2008, through June 5, 2009. Overall, 24 % of the arrivals had a positive QFT-IT, with the greatest frequency of positive results occurring in arrivals from Liberia (100 %) and Bhutan (39 %). More than the expected number of Burmese had indeterminate QFT-IT results. A positive QFT-IT was associated with age, race, ethnicity, and extent of TB burden in the country of origin. QFT-IT is useful to screen for LTBI in foreign-born arrivals, particularly middle-aged adults from high-burden countries. However, the QFT-IT may not yield meaningful results in groups with significant immunocompromise.

Journal

Journal of Immigrant and Minority HealthSpringer Journals

Published: Nov 24, 2012

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