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Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?

Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees? Indoleamine-2,3-dioxygenase (IDO) is an immunosuppressive enzyme that is expressed in tumours and enables them to escape immunologically mediated rejection. However, we are far from understanding the biological relevance of IDO expression during tumorigenesis. We need a better understanding of IDO biology to provide a rationale for the use of IDO inhibitors in the clinic. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Reviews Cancer Springer Journals

Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?

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References (139)

Publisher
Springer Journals
Copyright
Copyright © 2009 by Nature Publishing Group
Subject
Biomedicine; Biomedicine, general; Cancer Research
ISSN
1474-175X
eISSN
1474-1768
DOI
10.1038/nrc2639
Publisher site
See Article on Publisher Site

Abstract

Indoleamine-2,3-dioxygenase (IDO) is an immunosuppressive enzyme that is expressed in tumours and enables them to escape immunologically mediated rejection. However, we are far from understanding the biological relevance of IDO expression during tumorigenesis. We need a better understanding of IDO biology to provide a rationale for the use of IDO inhibitors in the clinic.

Journal

Nature Reviews CancerSpringer Journals

Published: Jun 1, 2009

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