Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Introduction

Introduction Familial Cancer (2005) 4: 209–210 DOI 10.1007/s10689-004-2526-4 Is syndromic terminology important in medical genet- Endometrial cancer is of even greater frequency in ics? McKusick must believe so, because his famous women who are harbingers of the MSH6 germline catalog of Mendelian Inheritance in Man contains more mutation. Other tumors which help to characterize the than 5000 entries of putative and confirmed hereditary syndrome include carcinoma of the ovary, stomach disorders, each providing nomenclature allowing the (particularly in Orientals: Japanese, Chinese, and Kore- reader to focus on a specific disorder by an appropriate ans), small bowel, hepatobiliary tract, breast, pancreas, ‘‘name,’’ thereby facilitating its ultimate identification upper urological tract, and brain. The inclusion of in the catalog. In the case of hereditary cancer the need breast cancer is controversial, but not in our mind; we for classification is burgeoning, particularly when one believe it is an integral cancer in a subset of Lynch considers the veritably explosive developments in syndrome kindreds. molecular genetics and how these developments may Many physicians now recognize the often complex cause terminology to be in flux as it relates to a specific syndrome through its cardinal features, i.e., the strik- germline mutation. Most importantly, once http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Familial Cancer Springer Journals

Introduction

Lynch, Henry
Familial Cancer , Volume 4 (3) – Sep 17, 2004
Download PDF
2 pages

Loading next page...
 
/lp/springer-journals/introduction-CPmwuRSoEM

References (0)

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Springer Journals
Copyright
Copyright © 2005 by Springer
Subject
Medicine & Public Health; Human Genetics; Oncology; Epidemiology
ISSN
1389-9600
eISSN
1573-7292
DOI
10.1007/s10689-004-2526-4
Publisher site
See Article on Publisher Site

Abstract

Familial Cancer (2005) 4: 209–210 DOI 10.1007/s10689-004-2526-4 Is syndromic terminology important in medical genet- Endometrial cancer is of even greater frequency in ics? McKusick must believe so, because his famous women who are harbingers of the MSH6 germline catalog of Mendelian Inheritance in Man contains more mutation. Other tumors which help to characterize the than 5000 entries of putative and confirmed hereditary syndrome include carcinoma of the ovary, stomach disorders, each providing nomenclature allowing the (particularly in Orientals: Japanese, Chinese, and Kore- reader to focus on a specific disorder by an appropriate ans), small bowel, hepatobiliary tract, breast, pancreas, ‘‘name,’’ thereby facilitating its ultimate identification upper urological tract, and brain. The inclusion of in the catalog. In the case of hereditary cancer the need breast cancer is controversial, but not in our mind; we for classification is burgeoning, particularly when one believe it is an integral cancer in a subset of Lynch considers the veritably explosive developments in syndrome kindreds. molecular genetics and how these developments may Many physicians now recognize the often complex cause terminology to be in flux as it relates to a specific syndrome through its cardinal features, i.e., the strik- germline mutation. Most importantly, once

Journal

Familial Cancer – Springer Journals

Published: Sep 17, 2004

There are no references for this article.