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Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia

Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia IDH1 and IDH2 mutations sensitize acute myeloid leukemia cells to the BCL-2 inhibitor ABT-199. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Medicine Springer Journals

Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia

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References (65)

Publisher
Springer Journals
Copyright
Copyright © 2014 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Biomedicine; Biomedicine, general; Cancer Research; Metabolic Diseases; Infectious Diseases; Molecular Medicine; Neurosciences
ISSN
1078-8956
eISSN
1546-170X
DOI
10.1038/nm.3788
Publisher site
See Article on Publisher Site

Abstract

IDH1 and IDH2 mutations sensitize acute myeloid leukemia cells to the BCL-2 inhibitor ABT-199.

Journal

Nature MedicineSpringer Journals

Published: Jan 19, 2015

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