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Localization of gene for human p53 tumour antigen to band 17p13

Localization of gene for human p53 tumour antigen to band 17p13 Recently the gene for the cellular tumour antigen p53, a phos-phoprotein found in increased concentration in a variety of human cells1, has been mapped to region 17q22 by in situ hybridization techniques and has been shown to translocate to the chromosome carrying the translocation [t(15 ; 17)] associated with acute pro-myelocytic leukaemia (APL)2. Based on this finding it has been postulated that this gene has a role in the pathogenesis of APL2. Here we present evidence that the gene for p53 is not located on the long arm of chromosome 17, but maps to band 17pl3. We therefore suggest that this gene is not directly involved in the chromosome translocation observed in APL. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Localization of gene for human p53 tumour antigen to band 17p13

Nature , Volume 320 (6057) – Mar 6, 1986

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References (16)

Publisher
Springer Journals
Copyright
Copyright © 1986 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/320084a0
Publisher site
See Article on Publisher Site

Abstract

Recently the gene for the cellular tumour antigen p53, a phos-phoprotein found in increased concentration in a variety of human cells1, has been mapped to region 17q22 by in situ hybridization techniques and has been shown to translocate to the chromosome carrying the translocation [t(15 ; 17)] associated with acute pro-myelocytic leukaemia (APL)2. Based on this finding it has been postulated that this gene has a role in the pathogenesis of APL2. Here we present evidence that the gene for p53 is not located on the long arm of chromosome 17, but maps to band 17pl3. We therefore suggest that this gene is not directly involved in the chromosome translocation observed in APL.

Journal

NatureSpringer Journals

Published: Mar 6, 1986

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