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Low incidence of KIT gene mutations and no PDGFRA gene mutations in primary cutaneous melanoma: an immunohistochemical and molecular genetic study of Japanese cases

Low incidence of KIT gene mutations and no PDGFRA gene mutations in primary cutaneous melanoma:... Int J Clin Oncol (2010) 15:453–456 DOI 10.1007/s10147-010-0087-0 O R I G IN AL ARTI CL E Low incidence of KIT gene mutations and no PDGFRA gene mutations in primary cutaneous melanoma: an immunohistochemical and molecular genetic study of Japanese cases Tadashi Terada Received: 2 March 2010 / Accepted: 9 April 2010 / Published online: 28 April 2010 Japan Society of Clinical Oncology 2010 Abstract inhibitors, for example imatinib, which are already used in Background Although several studies have reported the clinics for treatment of GIST, can also be used for incidence of KIT and PDGFRA gene mutations in cutane- melanoma. ous melanomas of Caucasians, only one report is available for Mongoloids, including Japanese. In Japan, melanoma is Keywords Cutaneous melanoma  KIT  PDGFRA an uncommon neoplasm compared with countries with Caucasian populations. Methods In this study, protein expression and gene Introduction mutations of these two genes were investigated by immu- nohistochemistry and PCR-direct sequencing in 12 primary Cutaneous melanoma is a highly malignant tumor, and cutaneous invasive melanomas of Japanese patients. Acral NRAS and BRAF mutations are mainly involved in the melanoma was detected in 2 cases, chronically sun-dam- pathogenesis of melanoma [1, 2]. The KIT gene, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Clinical Oncology Springer Journals

Low incidence of KIT gene mutations and no PDGFRA gene mutations in primary cutaneous melanoma: an immunohistochemical and molecular genetic study of Japanese cases

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References (18)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Japan Society of Clinical Oncology
Subject
Medicine & Public Health; Pathology; Internal Medicine; Diagnostic Radiology; Radiotherapy; Surgical Oncology; Oncology
ISSN
1341-9625
eISSN
1437-7772
DOI
10.1007/s10147-010-0087-0
pmid
20425130
Publisher site
See Article on Publisher Site

Abstract

Int J Clin Oncol (2010) 15:453–456 DOI 10.1007/s10147-010-0087-0 O R I G IN AL ARTI CL E Low incidence of KIT gene mutations and no PDGFRA gene mutations in primary cutaneous melanoma: an immunohistochemical and molecular genetic study of Japanese cases Tadashi Terada Received: 2 March 2010 / Accepted: 9 April 2010 / Published online: 28 April 2010 Japan Society of Clinical Oncology 2010 Abstract inhibitors, for example imatinib, which are already used in Background Although several studies have reported the clinics for treatment of GIST, can also be used for incidence of KIT and PDGFRA gene mutations in cutane- melanoma. ous melanomas of Caucasians, only one report is available for Mongoloids, including Japanese. In Japan, melanoma is Keywords Cutaneous melanoma  KIT  PDGFRA an uncommon neoplasm compared with countries with Caucasian populations. Methods In this study, protein expression and gene Introduction mutations of these two genes were investigated by immu- nohistochemistry and PCR-direct sequencing in 12 primary Cutaneous melanoma is a highly malignant tumor, and cutaneous invasive melanomas of Japanese patients. Acral NRAS and BRAF mutations are mainly involved in the melanoma was detected in 2 cases, chronically sun-dam- pathogenesis of melanoma [1, 2]. The KIT gene,

Journal

International Journal of Clinical OncologySpringer Journals

Published: Apr 28, 2010

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